O-Phospho-L-serine
- CAS No.
- 407-41-0
- Chemical Name:
- O-Phospho-L-serine
- Synonyms
- L O;P-ser;L-SOP;L-O-(RG);Seriphos;P-serine;Fosforina;3-P-SERINE;Phospho Ser;Phospho?Ser
- CBNumber:
- CB0456205
- Molecular Formula:
- C3H8NO6P
- Molecular Weight:
- 185.07
- MOL File:
- 407-41-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/13 17:03:25
| Melting point | 190 °C(lit.) |
|---|---|
| alpha | [α]D20 +14～+18°(c=5,dil.HCl) |
| Boiling point | 475.4±55.0 °C(Predicted) |
| Density | 1.809±0.06 g/cm3(Predicted) |
| vapor pressure | 0Pa at 20℃ |
| storage temp. | under inert gas |
| solubility | H2O: 50 mg/mL hot, clear, colorless to slightly yellow |
| form | Crystalline Powder |
| pka | pK1:2.08;pK2:5.65;pK3:9.74 (25°C) |
| color | White |
| Water Solubility | 28.34g/L at 20℃ |
| Merck | 14,7363 |
| BRN | 1726826 |
| InChIKey | BZQFBWGGLXLEPQ-UWTATZPHSA-N |
| CAS DataBase Reference | 407-41-0(CAS DataBase Reference) |
O-Phospho-L-serine price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P0878 | O-Phospho-L-serine | 407-41-0 | 10MG | ₹2803.68 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P3430 | Monoclonal Anti-Phosphoserine antibody produced in mouse clone PSR-45, ascites fluid | 407-41-0 | 100μL | ₹44055.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P3430 | Monoclonal Anti-Phosphoserine antibody produced in mouse clone PSR-45, ascites fluid | 407-41-0 | 0.2ML | ₹64180.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P0878 | O-Phospho-L-serine | 407-41-0 | 1G | ₹2890.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P0878 | O-Phospho-L-serine | 407-41-0 | 5G | ₹8768.25 | 2022-06-14 | Buy |
O-Phospho-L-serine Chemical Properties,Uses,Production
Description
O-
Chemical Properties
White powder
Uses
O-Phospho-L-Serine is an agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6 (EC50s = 2-5 μM). It mimics the phosphatidylserine head group and has been shown to inhibit the proliferation of microglia and to enhance neuronal differentiation of progenitor cells.
General Description
Monoclonal Anti-Phosphoserine (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.
Biological Activity
Group III metabotropic glutamate receptor agonist; analog of L-AP4 (L-(+)-2-Amino-4-phosphonobutyric acid ). Inhibits proliferation and enhances neuronal differentiation in progenitor cells.
Purification Methods
Recrystallise the phospho-serine by dissolving 10g in H2O (150mL) at 25o, stirring for up to 20minutes. Undissolved material is filtered off (Büchner), and 95% EtOH (85mL) is added dropwise during 4minutes, and set aside at 25o for 3hours, then at 3o overnight. The crystals are washed with 95% EtOH (100mL), then dry Et2O (50mL), and dried in a vacuum (yield 6.5g). A further quantity (1.5g) can be obtained by keeping the mother liquors and washings at -10o for 1 week. The DL-isomer has m 167-170o(dec) after recrystallisation from H2O/EtOH or MeOH. [Neuhaus & Korkes Biochemical Preparations 6 75 1958, Neuhaus & Byrne J Biol Chem 234 113 1959, IR: F.lsch & Mellander Acta Chem Scand 11 1232 1957, Beilstein 4 IV 3120.]
O-Phospho-L-serine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Maas Pharma Chemicals | +91-9958666224 | Delhi, India | 1607 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20308 | 58 | Inquiry |
| Hebei Saisier Technology Co., LTD | +86-18400010335 +86-18034520335 | China | 989 | 58 | Inquiry |
| Hebei Longbang Technology Co., LTD | +86-18032476855 +86-18032476855 | China | 948 | 58 | Inquiry |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | China | 10318 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
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