ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Epigenetics >DNA Methyltransferase Inhibitors >Lomeguatrib
Lomeguatrib
- CAS No.
- 192441-08-0
- Chemical Name:
- Lomeguatrib
- Synonyms
- C521206;CS-1103;AI3 27596;BRN1861032;Lomeguatrib;Lomeguqtrib;BRN 1861032;BRN-1861032;Lomeguaritrib;Lomeguatrib, >=98%
- CBNumber:
- CB11261272
- Molecular Formula:
- C10H8BrN5OS
- Molecular Weight:
- 326.17
- MOL File:
- 192441-08-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Boiling point | 683.8±65.0 °C(Predicted) |
|---|---|
| Density | 2.07 |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | DMSO: soluble10mg/mL, clear |
| pka | 9.42±0.10(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UO7420000 | |||||||||
| NFPA 704 |
|
Lomeguatrib price More Price(2)
Lomeguatrib Chemical Properties,Uses,Production
Uses
O6-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein which removes an alkyl group from the O6 position on guanine in an autoinactivating reaction. Although important in normal DNA repair, this reaction confers resistance to treatments that use O6-alkylating agents to produce cytotoxicity, e.g., in cancer. Lomeguatrib is a modified quanine base which acts as a pseudosubstrate inactivator of MGMT (IC50 = ~3 nM). A non-toxic compound, lomeguatrib completely inactivates MGMT in human prostate and colorectal tumors when given as a single 120 mg oral dose and in primary central nervous system cancers at 160 mg.
Lomeguatrib Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 126)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30250 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24099 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| Alfa Chemistry | United States | 24072 | 58 | Inquiry | |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| A.J Chemicals | 58 |
| ATK CHEMICAL COMPANY LIMITED | 60 |
| BOC Sciences | 58 |
| CONIER CHEM AND PHARMA LIMITED | 58 |
| TargetMol Chemicals Inc. | 58 |
| Career Henan Chemica Co | 58 |
| Dideu Industries Group Limited | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | 58 |
| Alfa Chemistry | 58 |
| InvivoChem | 58 |
192441-08-0(Lomeguatrib)Related Search:
chevron_left
1of4
chevron_right
Lomeguatrib
2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine
6-[(4-bromothiophen-2-yl)methoxy]-7H-purin-2-amine
6-((4-Bromo-2-thienyl)methoxy)purin-2-amine
C521206
2-AMino-6-(4-broMothiophen-2-ylMethoxy)-9H-purine
6-[(4-BroMo-2-thienyl)Methoxy]
-1H-purin-2-aMine
6-[(4-BroMo-2-thienyl)Methoxy]-9H-purin-2-aMine
LoMeguatrib(PaTrin-2)
2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine Lomeguatrib(PaTrin-2)
2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine Lomeguatrib
Lomeguatrib
2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine
Lomeguqtrib
Lomeguaritrib
Lomeguatrib, >=98%
CS-1103
PATRIN 2; PATRIN-2
9H-Purin-2-amine, 6-[(4-bromo-2-thienyl)methoxy]-
Lomeguatrib USP/EP/BP
6-((4-Bromothiophen-2-yl)methoxy)-9H-purin-2-amine
AI3 27596
BRN 1861032
BRN1861032
BRN-1861032
192441-08-0
C10H8BrN5OS
Inhibitors
Inhibitor of MGMT.
Epigenetics