Febantel
- CAS No.
- 58306-30-2
- Chemical Name:
- Febantel
- Synonyms
- rintal;Febantel;Febante1;bayvh5757;Bay h-5757;FEBANTEL EP;Febantel CRS;Febantel EP/BP;Febantel powder;Febantel Standard
- CBNumber:
- CB2502427
- Molecular Formula:
- C20H22N4O6S
- Molecular Weight:
- 446.48
- MOL File:
- 58306-30-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:04
| Melting point | 129-130°C |
|---|---|
| Boiling point | 215°C (rough estimate) |
| Density | 1.2962 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform (Sparingly) |
| form | Solid |
| pka | 7.60±0.46(Predicted) |
| color | White to Off-White |
| Merck | 14,3944 |
| InChI | InChI=1S/C20H22N4O6S/c1-28-12-17(25)21-16-11-14(31-13-7-5-4-6-8-13)9-10-15(16)22-18(23-19(26)29-2)24-20(27)30-3/h4-11H,12H2,1-3H3,(H,21,25)(H2,22,23,24,26,27) |
| InChIKey | HMCCXLBXIJMERM-UHFFFAOYSA-N |
| SMILES | N(C1C=C(SC2C=CC=CC=2)C=CC=1/N=C(\NC(=O)OC)/NC(=O)OC)C(=O)COC |
| CAS DataBase Reference | 58306-30-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301+P312+P330 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| WGK Germany | 3 |
| RTECS | FB3955000 |
| HS Code | 2930902000 |
Febantel price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 33981 | Febantel VETRANAL?, analytical standard | 58306-30-2 | 100MG | ₹10370.35 | 2022-06-14 | Buy |
| TCI Chemicals (India) | F0922 | Febantel | 58306-30-2 | 1G | ₹8800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | F0922 | Febantel | 58306-30-2 | 5G | ₹19800 | 2022-05-26 | Buy |
Febantel Chemical Properties,Uses,Production
Description
Febantel [N-2-( [2,3-bis-(methoxycarbonyl)-guanidine] 5- phenylthio)-phenyl) -2-methoxyacetamide] is a new anthelmintic that is highly active against various species of nematodes and cestodes in rodents, sheep, cattle, and horses. In 1978, febantel was introduced to South Africa under the trade name of Rintal? as a sheep drench, and to New Zealand as a sheep and cattle drench, and the USA and Australia as a paste for horse[1].
Chemical Properties
Febantel is White to Off-White Solid
in vivo
In vivo assays indicated that febantel exhibited potent anthelmintic activity against G. kobayashii with an EC50 value of 0.03 mg/L and 100 % anthelmintic efficacy at 0.1 mg/L after 48 h of exposure. Moreover, in vivo trials also revealed a notable post-treatment effect of febantel, where infected goldfish transferred to drug-free water after short 6-h exposure could still result in full eradication of the worms, indicating febantel might induce persistent perturbations in parasite physiology[1].
in vivo
In vitro assays showed a negative correlation between febantel concentrations and the survival of G. Kobayashi. However, increasing the febantel concentration to 2.0 mg/L did not result in the complete death of all worms. Oral administration of febantel demonstrated limited anthelmintic activity, with only 49 % efficacy at 200 mg/kg body weight daily over five days. Acute toxicity assays revealed that the 48-h LC50 value of febantel was 5.47 mg/L, 182.23 times higher than the 48-h EC50 value, indicating that febantel has a favorable safety profile. However, febantel exposure potentially interfered with hepatic metabolism and oxidative status, as indicated by variations in SOD, GST, and P450 gene expression[1].
References
[1] Thomas, H. “Ovacidal activity of febantel.” New Zealand veterinary journal 27 12 (1979): 273–5.
Febantel Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| NGL Fine Chem limited | +91-8866366396 +91-8866366396 | Mumbai, India | 26 | 58 | Inquiry |
| Afton Pharma | +91-9712000202 +91-9712000202 | Gujarat, India | 63 | 58 | Inquiry |
| Adani Wilmar Limited | +91-7383819375 +91-9099656790 | Gujarat, India | 34 | 58 | Inquiry |
| VIVIN DRUGS AND PHARMACEUTICALS LTD | +91-22670456625 +91-224067045635 | Telangana, India | 22 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Humble Healthcare Limited | +91-9720093000 +91-8006400378 | Uttar Pradesh, India | 141 | 58 | Inquiry |
| Manasvi Life Sciences | +91-9391326151 +91-9490072008 | Hyderabad, India | 39 | 58 | Inquiry |
| Alivira Animal Health Ltd | +91-8976959415 +91-9920774050 | Maharashtra, India | 35 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| NGL Fine Chem limited | 58 |
| Afton Pharma | 58 |
| Adani Wilmar Limited | 58 |
| VIVIN DRUGS AND PHARMACEUTICALS LTD | 58 |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | 58 |
| Humble Healthcare Limited | 58 |
| Manasvi Life Sciences | 58 |
| Alivira Animal Health Ltd | 58 |
| Ralington Pharma | 58 |
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