Fenbendazole
- CAS No.
- 43210-67-9
- Chemical Name:
- Fenbendazole
- Synonyms
- fenbendazol;Febendazole;5-(phenylthio)-2-benzimidazolecarbamic acid methyl ester;Methyl (6-(phenylthio)-1H-benzo[d]iMidazol-2-yl)carbaMate;[5-(Phenylthio)-1H-benzimidazol-2-yl]carbonic acid, Methyl ester;hoe881;Axilur;Fenbion;PANACUR;HOE-881V
- CBNumber:
- CB9154575
- Molecular Formula:
- C15H13N3O2S
- Molecular Weight:
- 299.35
- MOL File:
- 43210-67-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/21 22:41:43
| Melting point | 233°C |
|---|---|
| Density | 1.2767 (rough estimate) |
| refractive index | 1.6740 (estimate) |
| storage temp. | 2-8°C |
| Water Solubility | Insoluble in water |
| solubility |
DMSO:16.67(Max Conc. mg/mL);55.69(Max Conc. mM) DMF:10.0(Max Conc. mg/mL);33.41(Max Conc. mM) |
| pka | 10.80±0.10(Predicted) |
| form | Solid |
| color | White to Light yellow |
| Merck | 14,3960 |
| BRN | 759077 |
| InChI | InChI=1S/C15H13N3O2S/c1-20-15(19)18-14-16-12-8-7-11(9-13(12)17-14)21-10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19) |
| InChIKey | HDDSHPAODJUKPD-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)NC1NC2=CC(SC3=CC=CC=C3)=CC=C2N=1 |
| CAS DataBase Reference | 43210-67-9(CAS DataBase Reference) |
| EPA Substance Registry System | Carbamic acid, N-[6-(phenylthio)-1H-benzimidazol-2-yl]-, methyl ester (43210-67-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361fd-H373-H410 |
| Precautionary statements | P201-P202-P260-P273-P280-P308+P313 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-24/25 |
| WGK Germany | 2 |
| RTECS | DD6520500 |
| HS Code | 29339900 |
| Toxicity | dog,LD50,oral,> 500mg/kg (500mg/kg),Pesticide Science. Vol. 8, Pg. 550, 1977. |
Fenbendazole price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | F5396 | Fenbendazole ≥98% | 43210-67-9 | 5G | ₹7631.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1832 | Fenbendazole Pharmaceutical Secondary Standard; Certified Reference Material | 43210-67-9 | 200MG | ₹15144.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | F5396 | Fenbendazole ≥98% | 43210-67-9 | 100G | ₹35495.18 | 2022-06-14 | Buy |
| Sigma-Aldrich | 35032 | Fenbendazole VETRANAL?, analytical standard | 43210-67-9 | 100MG | ₹4784.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 35032 | Fenbendazole VETRANAL?, analytical standard | 43210-67-9 | 100MG | ₹4784.65 | 2022-06-14 | Buy |
Fenbendazole Chemical Properties,Uses,Production
Description
Fenbendazole is a benzimidazole anthelmintic. It is active against Giardia in vitro (IC50 = 0.3 μM). Fenbendazole (20 mg/kg) prevents infiltration of parasites into the brain in a rabbit model of E. cuniculi infection. Fenbendazole also activates HIF-1α and prevents oxidative stress-induced death in primary neurons in vitro.
Chemical Properties
Off-White Solid
Uses
Fenbendazole is a benzimidazole anthelmintic that is metabolised in mammals to a series of other benzimidazoles including oxfendazole. It is used for the control of gastrointestinal roundworms, lung worms, Nematodes and tape worms. It is the only benzimidazole approved for use in organic livestock production.
Uses
Fenbendazole is a medication used to treat parasites, mainly in dogs. However, studies have found that in a group of mice treated with a combination of fenbendazole and vitamins, tumor growth inhibition was unexpected It may be because it interferes with the uptake of glucose by cancer cells, which is essential for tumor growth and proliferation. It prevents cancer cells from obtaining the glucose needed to grow and divide to inhibit the growth of cancer cells. Studies have found that fenbendazole can kill cancer cells and promote tumor regression in patients with metastatic large B-cell lymphoma, and also plays a role in other metastatic malignant tumors such as bladder cancer and renal cell carcinoma. It is currently being treated in combination with other anti-cancer drugs to study its anti-cancer potential[1-3].
Definition
ChEBI: Fenbendazole is a member of the class of benzimidazoles that is 1H-benzimidazole which is substituted at positons 2 and 5 by (methoxycarbonyl)amino and phenylsulfanediyl groups, respectively. A broad-spectrum anthelmintic, it is used, particularly in veterinary medicine, for the treatment of nematodal infections. It has a role as an antinematodal drug. It is a member of benzimidazoles, a carbamate ester and an aryl sulfide.
General Description
Fenbendazole is a thio substituted benzimidazole, which belongs to the group of anthelmintics. It can be widely used in veterinary medicine particularly, in the treatment of helminth infections.
Side effects
According to the results of toxicological studies, fenbendazole appears to be a safe drug, but up to 5% of people may experience stomach pain or diarrhea if taken in large amounts without interruption. People with severe renal failure or liver failure have a reduced level of drug excretion, and since fenbendazole powder is metabolized mainly in the liver, long-term heavy use can cause an asymptomatic increase in liver enzymes.
Mode of action
Fenbendazole is a benzimidazole antiparasitic drug that works at the sub-cellular level preventing cell division. Benzimidazoles bind to the β-tubulin, inhibiting the cell’s microtubule assembly responsible for intracellular transport and required for mitotic cellular division. In effect, it starves the parasite by causing intestinal cell disruption.
References
[1] Gao P, et al. Unexpected antitumorigenic effect of fenbendazole when combined with supplementary vitamins. Journal of the American Association for Laboratory Animal Science : JAALAS, 2008.
[2] Park D, et al. Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells. The Korean Journal of Physiology Pharmacology, 2022; 26: 377-387.[3] Shin Y, et al. Anticancer Evaluation of Methoxy Poly(Ethylene Glycol)-b-Poly(Caprolactone) Polymeric Micelles Encapsulating Fenbendazole and Rapamycin in Ovarian Cancer. International Journal of Nanomedicine, 2023; 2023: 2209—2223.
Fenbendazole Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| THE MOLECULEZ | +91-7506703683 +91-7506703683 | Maharashtra, India | 79 | 58 | Inquiry |
| NGL Fine Chem limited | +91-8866366396 +91-8866366396 | Mumbai, India | 26 | 58 | Inquiry |
| SNECOFRi Pvt Ltd | +91-9032850129 +91-9032850129 | Telangana, India | 404 | 58 | Inquiry |
| Reenold Enterprises | +91-8208173540 +91-8208173540 | Maharashtra, India | 28 | 58 | Inquiry |
| Gonane Pharma | +91-9819380043 +91-9819380043 | NaviMumbai, India | 192 | 58 | Inquiry |
| Murli Krishna Exports Pvt Ltd | +91-2225631595 +91-2225631594 | New Delhi, India | 185 | 58 | Inquiry |
| Siflon Drugs | +917780793600 | Hyderabad, India | 12 | 58 | Inquiry |
| Adani Wilmar Limited | +91-7383819375 +91-9099656790 | Gujarat, India | 34 | 58 | Inquiry |
| Supharma Chem | +91-9428180908 +91-9428180908 | Gujarat, India | 10 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| THE MOLECULEZ | 58 |
| NGL Fine Chem limited | 58 |
| SNECOFRi Pvt Ltd | 58 |
| Reenold Enterprises | 58 |
| Gonane Pharma | 58 |
| Murli Krishna Exports Pvt Ltd | 58 |
| Siflon Drugs | 58 |
| Adani Wilmar Limited | 58 |
| Supharma Chem | 58 |
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