LORCASERIN
- CAS No.
- 616202-92-7
- Chemical Name:
- LORCASERIN
- Synonyms
- Apd356;Ar-10a;CS-1994;Apd-356;Apd 356;LORCASERIN;LORCASERIN API;Unii-637E494o0z;Lorcaserin powder;Lotcaserin Freebase
- CBNumber:
- CB61011744
- Molecular Formula:
- C11H14ClN
- Molecular Weight:
- 195.69
- MOL File:
- 616202-92-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/7 19:13:26
| Boiling point | 288 ºC |
|---|---|
| Density | 1.075 |
| Flash point | 128 ºC |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Light Beige to Beige Semi-Solid |
| pka | 9.99±0.40(Predicted) |
| Stability | Hygroscopic |
| InChI | InChI=1S/C11H14ClN/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9/h2-3,6,8,13H,4-5,7H2,1H3/t8-/m0/s1 |
| InChIKey | XTTZERNUQAFMOF-QMMMGPOBSA-N |
| SMILES | N1CCC2=CC=C(Cl)C=C2[C@@H](C)C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H410-H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P273-P391-P501 |
LORCASERIN Chemical Properties,Uses,Production
Chemical Properties
Yellow Oil
Uses
Lorcaserin was used to treat Opioid Use Disorder (OUD).
Definition
ChEBI: A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine substituted at position 1 by a methyl group and a t position 6 by a chloro group.
Mechanism of action
Lorcaserin acts at 5-HT2C receptors in the central nervous system (CNS), particularly the hypothalamus, to reduce appetite.
Side effects
- constipation
- dry mouth
- excessive tiredness
- pain in the back or muscles
- headache
- dizziness
- difficulty falling asleep or staying asleep
- anxiety
Synthesis
The synthesis of LORCASERIN is as follows:
Liquid precursor 53 11-HCl (0.5mmol) was placed into a test tube equipped with a magnetic stir bar. Anhydrous 44 AlCl3 (1.75 equiv according to starting material) was added and efficiently mixed to obtain a paste. The mixture was slowly heated (10°C/min) to 150°C and stirred overnight. A saturated solution of 54 NaCl was added and the mixture was cooled. The pH was adjusted to 9.5-10 using 1M NaOH and then extracted with EtOAc. The combined organic phases were washed with brine, dried over Na2SO4 and the solvent was evaporated under reduced pressure. The obtained crude mixture was analyzed using 1H NMR spectroscopy (estimated yield by 1H NMR was 62%).
LORCASERIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Viyash Life Sciences Pvt Ltd | +91-4023635052 +91-4023635052 | Telangana, India | 213 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Wuhan Demeikai Biotechnology Co., Ltd | +8618942921723 | China | 723 | 58 | Inquiry |
| Hubei Langyou International Trading Co., Ltd | +8618874586545 | China | 197 | 58 | Inquiry |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | China | 985 | 58 | Inquiry |
| Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 | China | 293 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21675 | 55 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9338 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29900 | 58 | Inquiry |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | China | 2931 | 58 | Inquiry |
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