ChemicalBook > Product Catalog >API >Hormones and the Endocrine System >Pancreatic hormone and blood sugar regulation >Albiglutide

Albiglutide

Albiglutide Structure
CAS No.
782500-75-8
Chemical Name:
Albiglutide
Synonyms
Albugon;Gsk 716155;albiglutide;Naliglutide;Unii-5E7U48495e;Albiglutide Fragment;Albiglutide(Acetate);Albiglutide USP/EP/BP;Research Grade Albiglutide;Albiglutide Eperzan Tanzeum
CBNumber:
CB61518490
Molecular Formula:
C148H223N39O46
Molecular Weight:
3284.58792
MOL File:
782500-75-8.mol
Modify Date:
2024/11/13 11:39:26

Albiglutide Properties

storage temp. Store at -20°C
Water Solubility Water: 100 mg/mL (30.45 mM);
InChIKey OGWAVGNOAMXIIM-VTAHJYCESA-N

Albiglutide Chemical Properties,Uses,Production

General Description

Albiglutide (also known as naliglutide, GSK 716155) isa sequential dimer of GLP-1(7–36)(Ala8→Gly) covalentlylinked to modified human serum albumin (i.e., it is a “fusionprotein” with modified HSA). This molecule is currentlywell into phase III clinical trials. Although albiglutide,if marketed (Syncria, GlaxoSmithKline), will—likeexenatide—be administered by injection, the half-life andduration of 6 to 7 days would allow for weekly administration.

Enzyme inhibitor

This GLP-1 agonist and anti-diabetic drug (MW = 72.9 kDa; CAS 782500- 75-8), marketed as Eperzan? and Tanzeum?, by GlaxoSmithKline (GSK) is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide has a half-life of 4-7 days, commending it for biweekly or weekly administration in the treatment of Type 2 diabetes. The half-life is considerably longer than exenatide (Byetta?) and liraglutide (Victoza?).

Albiglutide Preparation Products And Raw materials

Raw materials

Preparation Products

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albiglutide Albugon Naliglutide 7-36-Glucagon-like peptide I (8-glycine) (human), fusion protein with 7-36-glucagon-like peptide I (8-glycine) (human) fusion protein with serum Gsk 716155 Unii-5E7U48495e 7-36-Glucagon-likepeptide I [8-glycine] (huMan), fusion protein with 7-36-glucagon-like peptide I[8-glycine] (huMan) fusion protein with seruM albuMin (huMan) Albiglutide Fragment Albiglutide USP/EP/BP Albiglutide(Acetate) Research Grade Albiglutide Albiglutide Eperzan Tanzeum Albiglutide GLP-1 Naliglutide 782500-75-8 GLP