Chlorprothixene
- CAS No.
- 113-59-7
- Chemical Name:
- Chlorprothixene
- Synonyms
- CPX;CPO;n714;CPOX;mk184;N 714;n714c;Paxyl;MK 184;N 714C
- CBNumber:
- CB6361448
- Molecular Formula:
- C18H18ClNS
- Molecular Weight:
- 315.86
- MOL File:
- 113-59-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/7/21 17:23:12
| Melting point | 97-98° |
|---|---|
| Boiling point | 160 °C(Press: 0.04 Torr) |
| Density | 1.1048 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO : 33.33 mg/mL (105.52 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) |
| form | powder to crystal |
| pka | pKa 8.4(H2O) (Uncertain) |
| color | White to Orange to Green |
| Water Solubility | 385.8ug/L(22.5 ºC) |
| Stability | Hygroscopic |
| NIST Chemistry Reference | Chlorprothixene(113-59-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H336 | |||||||||
| Precautionary statements | P301+P310+P330 | |||||||||
| HS Code | 2934.99.3000 | |||||||||
| Toxicity | LD50 oral in rabbit: 182mg/kg | |||||||||
| NFPA 704 |
|
Chlorprothixene price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemicals (India) | C3505 | Chlorprothixene min. 97.0 % | 113-59-7 | 250MG | ₹3600 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C3505 | Chlorprothixene min. 97.0 % | 113-59-7 | 1G | ₹6000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C3505 | Chlorprothixene min. 97.0 % | 113-59-7 | 5G | ₹8000 | 2022-05-26 | Buy |
Chlorprothixene Chemical Properties,Uses,Production
Description
In 2002, the American Association of Poison Control Centers’ Toxic Exposure Surveillance System reported 5224 human exposures to phenothiazines, thioxanthenes, and other neuroleptic medications; 3691 were in adults and 808 in children. Unintentional and intentional exposures accounted for 43.7 and 47.8%, respectively. There were 417 (8.0%) adverse drug reactions reported. Thioxanthenes are chemical compounds in which the oxygen atom in xanthene is replaced with a sulfur atom. They are also related to phenothiazines. Several derivatives are used as typical antipsychotics in the treatment of schizophrenia and other psychoses. The thioxanthenes, as a class, are closely related chemically to the phenothiazines. The major structural difference is that the nitrogen at position 10 in the phenothiazines is replaced by a carbon atom with a double bond to the side chain, as shown in the chemical structure of flupenthixol, which has a double-bonded carbon in the number 10 position. Clopenthixol is a typical antipsychotic drug of the thioxanthenes class and a racemic mixture of cis and trans isomers. Zuclopenthixol, the pure cis isomer, has been much more widely used. Both drugs are equally effective as antipsychotics and have similar adverse effect profiles, but clopenthixol is half as active on a milligram-to-milligram basis and appears to produce more sedation in comparison.
Uses
Chlorprothixene has an antipsychotic and sedative action. It has expressed antiemetic activity. It is used in various psychoses, schizophrenia, reactive and neurotic depression with prevalent anxious symptomatology, and in conditions of excitement associated with fear and stress. It may be used in small doses as a sedative agent in neurosis.
Environmental Fate
Long-range transport: handling of thioxanthenes should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. In case of handling, avoid inhalation and contact with skin, eyes, and clothing, as these materials may be an irritant. These substances are considered nonhazardous for transport.
Chlorprothixene Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | China | 6387 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
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