Tolmetin sodium
- CAS No.
- 35711-34-3
- Chemical Name:
- Tolmetin sodium
- Synonyms
- TOLECTIN;Sodium tolmetin;TOLMETIN SODIUM;Tolmetin Sodium Salt;Tolmetin sodium USP/EP/BP;sodium 1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate;sodium:2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetate;1-Methyl-5-p-toluoyl-1H-pyrrole-2-acetic acid sodium salt;1-Methyl-5-(p-toluoyl)-1H-pyrrole-2-acetic acid sodium salt;SodiuM 2-(1-Methyl-5-(4-Methylbenzoyl)-1H-pyrrol-2-yl)acetate
- CBNumber:
- CB6397353
- Molecular Formula:
- C15H14NNaO3
- Molecular Weight:
- 279.27
- MOL File:
- 35711-34-3.mol
- Modify Date:
- 2023/5/4 17:34:38
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
Tolmetin sodium Chemical Properties,Uses,Production
Uses
Tolmetin Sodium is a non-steroidal anti-inflammatory drug.
Pharmacokinetics
Tolmetin sodium is rapidly and almost completely absorbed on oral administration, with peak plasma levels being attained within the first hour of administration. It has a relatively short plasma half-life of approximately 1 hour because of extensive first-pass metabolism, involving hydroxylation of the p-methyl group to the primary alcohol, which is subsequently oxidized to the dicarboxylic acid.
Clinical Use
Tolmetin is synthesized straightforwardly from 1-methylpyrrole. It was introduced in the United States in 1976 and like other NSAIDs, inhibits prostaglandin biosynthesis. Tolmetin, however, also inhibits polymorph migration and decreases capillary permeability. Its anti-inflammatory activity, as measured in the carrageenan-induced rat paw edema and cotton pellet granuloma assays, is intermediate between those of phenylbutazone and indomethacin.
Side effects
The most frequently adverse reactions are those involving the GI tract (e.g., abdominal pain, discomfort, and nausea) but appear to be less than those observed with aspirin. The CNS effects (e.g., dizziness and drowsiness) also are observed. Few cases of overdosage have been reported, but in such cases, recommended treatment includes elimination of the drug from the GI tract by emesis or gastric lavage and elimination of the acidic drug from the circulatory system by enhancing alkalinization of the urine with sodium bicarbonate.
Metabolism
This metabolite is inactive in standard in vivo anti-inflammatory assays. The free acid (pKa = 3.5) is highly bound to plasma proteins (99%), and excretion of tolmetin and its metabolites occurs primarily in the urine.Approximately 15 to 20% of an administered dose is excreted unchanged and 10% as the glucuronide conjugate of the parent drug. Conjugates of the dicarboxylic acid metabolite account for the majority of the remaining administered drug.
Tolmetin sodium Preparation Products And Raw materials
Raw materials
Preparation Products
Tolmetin sodium Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 25247 | 58 | Inquiry |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | China | 49999 | 58 | Inquiry |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 15229059051 | China | 9980 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 4008200310 | China | 24016 | 58 | Inquiry |
| Hubei Shiteng Chemical Technology Co. LTD | 189-71850150 19086915685 | China | 4997 | 58 | Inquiry |
| Wuhan Xinyang Ruihe Chemical Technology Co., Ltd. | 13720181483 13720181483 | China | 4545 | 58 | Inquiry |
| Hubei widely chemical technology Co., Ltd. | 027-83989310 18627915365 | China | 1295 | 58 | Inquiry |
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