Isoflupredone
- CAS No.
- 338-95-4
- Chemical Name:
- Isoflupredone
- Synonyms
- 9-FLUOROPREDNISOLONE;NSC 12174;ISOFLUPREDONE;DELTAFLUDROCORTISONE;9α-Fluoro-1-cortisol;9a-fluoroprednisolone;Isoflupredone USP/EP/BP;9-ALPHA-FLUOROPREDNISOLONE;Isoflupredone Solution in Acetonitrile, 100μg/mL;1, 4-PREGNADIEN-9α-FLUORO-11β, 17, 21-TRIOL-3, 20-DIONE
- CBNumber:
- CB6440732
- Molecular Formula:
- C21H27FO5
- Molecular Weight:
- 378.43
- MOL File:
- 338-95-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/22 17:12:53
| Melting point | 260-262°C (dec.) |
|---|---|
| alpha | D23 +108° (c = 0.611 in ethanol); D23 +94° (alcohol)(Fried) |
| Boiling point | 566.7±50.0 °C(Predicted) |
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Ethanol (Slightly, Heated, Sonicated), Ethyl Acetate (Slightly) |
| form | Solid |
| pka | 12.10±0.70(Predicted) |
| color | White to Pale Brown |
| InChIKey | WAIJIHDWAKJCBX-MPVZUUJONA-N |
| SMILES | [C@@]12([H])CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@]1(C)[C@@](CC[C@@]21[H])(O)C(=O)CO |&1:0,10,12,14,17,19,22,r| |
Isoflupredone Chemical Properties,Uses,Production
Description
Isoflupredone, also known as deltafludrocortisone and 9α-fluoroprednisolone, is a synthetic glucocorticoid corticosteroid which was never marketed. Its acetate ester is isoflupredone acetate whch is widely used in veterinary medicine[1].
Chemical Properties
White Solid
Uses
Isoflupredone is an anti-inflammatory. Isoflupredone could be used as an internal standard in the determination of 12 glucocorticoids in bovine milk through liquid chromatography with tandem mass spectrometry[1]. It could be used to treat endometritis by increasing pregnancy rates[2]. Isoflupredone acetate is one of four Food and Drug Administration approved corticosteroids for intra-articular use in horses[3].
References
[1] Ma L, et al. Multiresidue analysis of glucocorticoids in milk by LC-MS/MS with low-temperature purification and dispersive solid-phase extraction. Journal of Separation Science, 2017; 40: 2759-2768.
[2] Wolf C, et al. Uterine nitric oxide levels and isofluopredone treatment effect in mares susceptible to persistent post-breeding endometritis. Animal Reproduction, 2016; 13: 100-104.
[3] Knych H, et al. Expression of inflammatory and structural matrix genes in synovial fluid following intra-articular administration of isoflupredone acetate to exercised horses. Equine Veterinary Journal, 2017; 50: 504-512.
Isoflupredone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Hebei Kangcang new material Technology Co., LTD | +8615713292910 | China | 341 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| Nanjing Shizhou Biotechnology Co., Ltd | +86-15850508050 +86-15850508050 | China | 323 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 9030 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | China | 13141 | 58 | Inquiry |
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