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ChemicalBook > Product Catalog >API >Synthetic Anti-infective Drugs >Antiseptics & Disinfectants Drugs >Chloramine-T

Chloramine-T

Chloramine-T Structure
CAS No.
127-65-1
Chemical Name:
Chloramine-T
Synonyms
CHLORAMINE T;Tosylchloramide sodium;SodiuM chloro(tosyl)aMide;halamid;chlorazan;MI 9;NF X;anexol;GANSIL;clorina
CBNumber:
CB7344990
Molecular Formula:
C7H7ClNNaO2S
Molecular Weight:
227.64
MOL File:
127-65-1.mol
Modify Date:
2024/7/25 20:04:51
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Chloramine-T Properties

Melting point 167-170 °C(lit.)
Density 1.401[at 20℃]
vapor pressure 0Pa at 25℃
storage temp. Sealed in dry,2-8°C
solubility H2O: >100 mg/mL
pka 0.39[at 20 ℃]
form Solid
color White to off-white
Water Solubility 150g/L at 25℃
Stability Stable. Incompatible with strong oxidizing agents. May decompose violently if heated above 130 C. May decompose on exposure to air.
InChI InChI=1S/C7H7ClNO2S.Na/c1-6-2-4-7(5-3-6)12(10,11)9-8;/h2-5H,1H3;/q-1;+1
InChIKey VDQQXEISLMTGAB-UHFFFAOYSA-N
SMILES S(=O)(=O)(N(Cl)[Na])C1C=CC(C)=CC=1
LogP -1.3 at 20℃
CAS DataBase Reference 127-65-1(CAS DataBase Reference)
EPA Substance Registry System Chloramine T (127-65-1)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes  C,Xn
Risk Statements  22-31-34-42
Safety Statements  22-26-36/37/39-45-7-1/2
RIDADR  UN 3263 8/PG 3
WGK Germany  2
HazardClass  8
PackingGroup  III
HS Code  29242990

Chloramine-T Chemical Properties,Uses,Production

Description

The sodium salt of p-toluenesulfochloramide, commonly known as chloramine-T, exerts strong oxidizing action in both acidic and alkaline media and thus has been widely used for the oxidimetric determination of a large number of inorganic and organic substances. Oxidation of some aldehydes by chloramine-T has been reported to occur quantitatively in an alkaline solution, giving the corresponding acid as the end product. Both direct and indirect methods have been carried out to estimate aldehydes by chloramine-T. Chloramine-T (CAT) is also commonly used in radiolabeling bioactive molecules by halogenation. CAT is used to release radioactive elemental iodine by oxidation of its salts. Unfortunately, CAT is a strong oxidizing agent and can cause significant damage to peptides and proteins. This may lower the yield of the iodination reaction and may produce undesirable side products[1-2]. 

Chemical Properties

white or yellow powder with a chlorine-like odour

Uses

This disinfectant is for external use only, it can exterminate bacteria, viruses, fungi, spore. The action principle is that chlorine can sterilize slowly and lastingly, and also can dissolve necrotic tissue, chlorine come from hypochlorous acid which is produced by Chloramine-T solution. Apply to disinfect drinking water container,food,all kind of tableware, fruits and vegetables,and cleaning wound, mucous membrane.

Definition

ChEBI: An organic sodium salt derivative of toluene-4-sulfonamide with a chloro substituent in place of an amino hydrogen.

Safety Profile

Poison by parenteral and intravenous routes. Human mutagenic data reported. When heated to decomposition it emits toxic fumes of Cl-, SOx, Na2O, and NOx. See also SULFONATES and CHLORIDES.

Synthesis

Chloramine-T is prepared in 75 – 95 % yield by passing chlorine into a sodium hydroxide solution of p-toluenesulfonamide. It is a strong electrolyte in acid solution and a good oxidizing agent in base. It is fairly soluble in water, and practically insoluble in benzene, chloroform, and ether. The compound reacts readily with mustard gas to yield a harmless crystalline sulfimide; chloramine-T derivatives are being studied as protective agents against poison gas.
synthesis of Chloramine-T

References

[1] M. C. Agrawal, S. P. Mushran. "Mechanism of Oxidation of some Aliphatic Aldehydes by Chloramine-T." Zeitschrift für Naturforschung B 20 1 (1972): 401–404.
[2] B M Tashtoush. "Chloramine-T in radiolabeling techniques. IV. Penta-O-acetyl-N-chloro-N-methylglucamine as an oxidizing agent in radiolabelling techniques." Analytical biochemistry 288 1 (2001): 16–21.

Chloramine-T Preparation Products And Raw materials

Raw materials

Sodium hypochlorite Saccharin Water Tosyl chloride

Preparation Products

Hydrazinium hydroxide solution o-Chlorobenzenesulfonamide Hydrazine hydrate 5-Bromo-2-methoxypyrimidine Dimethylcarbamoyl chloride
HYDRAZINE Methylhydrazine 4-Amino-6-chlorobenzene-1,3-disulfonamide Benzenesulfonamide,N,N-dibromo-4-methyl- 4-Ethylbenzene-1-sulfonyl chloride
4-aminobutyronitrile 4-tert-Butylbenzenesulfonyl chloride Aziridine, 2-ethenyl-1-[(4-methylphenyl)sulfonyl]-
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Chloramine-T Suppliers

Global( 451)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CRYSTAL PHARMA +91-9322218073 +91-9820141331 Mumbai, India 106 58 Inquiry
Narsipur Chemicals Pvt Ltd +91-9653191286 +91-9869641483 Maharashtra, India 5 58 Inquiry
Melzer Chemicals Pvt Ltd +91-2041004800 +91-2041004800 Maharashtra, India 17 58 Inquiry
Vijaya Pharma And Life Science +91-8939866271 +91-8939866271 Tamil Nadu, India 320 58 Inquiry
dkpharmachem 91 -251 -2690366 New Delhi, India 60 46 Inquiry
Central Drug House(P) Ltd. 91-11-49404040 New Delhi, India 6160 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Crystal Pharma 08048600611 Mumbai, India 88 58 Inquiry
Shree Ganesh Dye Chem 08068442225Ext 624 Ahmedabad, India 48 58 Inquiry
Mass Dye Chem Private Limited 08048371956Ext 831 Pune, India 16 58 Inquiry
Supplier Advantage
CRYSTAL PHARMA 58
Narsipur Chemicals Pvt Ltd 58
Melzer Chemicals Pvt Ltd 58
Vijaya Pharma And Life Science 58
dkpharmachem 46
Central Drug House(P) Ltd. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Crystal Pharma 58
Shree Ganesh Dye Chem 58
Mass Dye Chem Private Limited 58

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Chloramine-T Spectrum

Chloramine-T(127-65-1)13CNMRChloramine-T(127-65-1)IR1Chloramine-T(127-65-1)IR2

127-65-1(Chloramine-T)Related Search:

Sodium chlorite Sodium bicarbonate Sodium citrate Sodium chloride Sodium acetate
4-Chlorobenzenesulfonyl chloride Sodium sulfate p-Toluenesulfonamide Sodium p-toluenesulfonate Tosyl chloride
4-Methylbenzenesulfonhydrazide 4-Nitrobenzenesulfonyl chloride N-Acetylsulfanilyl chloride Sodium hydroxide 4-Methoxybenzenesulfonyl chloride
Sodium benzoate 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Difluorochloromethane
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chlorazene chlorosol chlorozone chlorseptol clorina clorosan desinfect gyneclorina heliogen kloramin kloramine-t mannolite monochloraminet multichlor N-Chloro-4-methylben-zenesulfonamide n-chloro-4-methylbenzenesulfonamidesodiumsalt n-chloro-4-methyl-benzenesulfonamidsodiumsalt n-chloro-4-methylbenzylsulfonamidesodiumsalt N-Chloro-4-tolunesulfonamide,sodiumsalt n-chloro-p-toluenesulfonamidesodium n-chloro-p-toluenesulfonamidsodiumsalt n-chlorotoluenesulfonamidesodiumsalt sodiumchloraminet sodiumn-chloro-p-toluenesulfonamide sodiump-toluenesulfonylchloramide sodiumtosylchloramide tampules tochlorine tolamine tosylchloramide TN-Chloro-4-toluenesulfonaMide sodiuM salt(HALAMID) BenzenesulfonaMide,N-chloro-4-Methyl-, sodiuM salt (1:1) P-TOLUENESULFONCHLORAMIDE SODIUM SALT SODIUM-P-TOLUENESULFONCHLORAMIDE N-CHLORO-4-METHYL-BENZENESULFONAMIDE SODIUM N-CHLORO-4-TOLUENESULFONAMIDE, SODIUM SALT N-CHLORO-P-TOLUENESULPHONAMIDE, SODIUM SALT N-CHLORO-P-TOLUENESULFONAMIDE SODIUM SALT MONOCHLORAMINE REAGENT MIANINE Chloramine T (Tosyl Chloramide Sodium Salt) (n-chloro-p-toluenesulfonamido)sodium acti-chlore aktivin anexol Benzenesulfonamide,N-chloro-4-methyl-,sodiumsalt IODO-BEADS(R) GYNECHLORINA EUCLORINA GANSIL CHLORAZONE CHLORAMINE T POLYMER BOUND CHLORAMINE T SODIUM CHLORASEPTINE N-Chloro-P-Toluenesulfonamide Odium Salt ChloramineT,A.R. p-ChloramineThydrate ChloramineT,99.5%