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Tazobactam acid

Tazobactam acid Structure
CAS No.
89786-04-9
Chemical Name:
Tazobactam acid
Synonyms
TAZOBACTAM;(2S,3S,5R)-3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide;ytr83oh;YTR-830H;cl298741;Tazobactamum;7-Methyl-2H-1;He (the temple;TAZOBACTAN ACID;tazobactam acid
CBNumber:
CB7473784
Molecular Formula:
C10H12N4O5S
Molecular Weight:
300.29
MOL File:
89786-04-9.mol
MSDS File:
SDS
Modify Date:
2024/8/2 18:12:07
Request For Quotation

Tazobactam acid Properties

Melting point 115-145℃
Boiling point 77℃
Density 1.92±0.1 g/cm3(Predicted)
RTECS XI0191400
Flash point >110°(230°F)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated)
form Solid
pka 2.33±0.40(Predicted)
color White to Off-White
Water Solubility Soluble in water
Stability Light Sensitive
InChI InChI=1S/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19/h2-3,7-8H,4-5H2,1H3,(H,16,17)/t7-,8+,10+/m1/s1
InChIKey LPQZKKCYTLCDGQ-WEDXCCLWSA-N
SMILES N12[C@@]([H])(CC1=O)S(=O)(=O)[C@@](C)(CN1C=CN=N1)[C@@H]2C(O)=O
CAS DataBase Reference 89786-04-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Danger
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
HS Code  2941106000
NFPA 704
0
2 0

Tazobactam acid price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) PHR1686 Tazobactam Pharmaceutical Secondary Standard; Certified Reference Material 89786-04-9 1G ₹9493.53 2022-06-14 Buy
TCI Chemicals (India) T3732 Tazobactam 89786-04-9 1G ₹4300 2022-05-26 Buy
TCI Chemicals (India) T3732 Tazobactam 89786-04-9 5G ₹10000 2022-05-26 Buy
Product number Packaging Price Buy
PHR1686 1G ₹9493.53 Buy
T3732 1G ₹4300 Buy
T3732 5G ₹10000 Buy

Tazobactam acid Chemical Properties,Uses,Production

Description

Tazobactam often is coadministered with piperacillin because of tazobactam's ability to inhibit β-lactamases. T azobactam, like other β-lactamase inhibitors, has little or no antibacterial activity. This effect is analogous to that of clavulanic acid and sulbactam.

Chemical Properties

White or off-white powder

Uses

b-lactamase inhibitor

Definition

ChEBI: A member of the class of penicillanic acids that is sulbactam in which one of the exocyclic methyl hydrogens is replaced by a 1,2,3-triazol-1-yl group; used (in the form of its sodium salt) in combination with ceftolozane sulfate for treatment of complicat d intra-abdominal infections and complicated urinary tract infections.

Antimicrobial activity

Tazobactam exhibits little useful antimicrobial activity, although weak activity against Acinetobacter spp. and Borrelia burgdorferi has been reported.

Mechanism of action

Tazobactam functions as an irreversible inhibitor by covalently binding to β-lactamases, and prevents the enzyme hydrolysis of ceftolozane, thereby enhancing its activity against resistant ESBL-producing pathogens, along with expanding coverage to include anaerobes (e.g., Bacteroides spp.)

Clinical Use

Tazobactam is a penicillanic acid sulfone that is similar instructure to sulbactam. It is a more potent β-lactamaseinhibitor than sulbactam and has a slightly broader spectrumof activity than clavulanic acid. It has very weak antibacterialactivity. Tazobactam is available in fixed-dose, injectablecombinations with piperacillin, a broad-spectrum penicillinconsisting of an 8:1 ratio of piperacillin sodium to tazobactamsodium by weight and marketed under the trade name Zosyn.The pharmacokinetics of the two drugs are very similar. Bothhave short half-lives (t1/2 ～1 hour), are minimally proteinbound, experience very little metabolism, and are excreted inactive forms in the urine in high concentrations.
Approved indications for the piperacillin–tazobactamcombination include the treatment of appendicitis, postpartumendometritis, and pelvic inflammatory disease caused byβ-lactamase–producing E. coli and Bacteroides spp., skin andskin structure infections caused by β-lactamase–producingS. aureus, and pneumonia caused by β-lactamase–producingstrains of H. influenzae.

Tazobactam acid Preparation Products And Raw materials

Raw materials

Sulbactam Sodium azide Ethanol Potassium bromide Potassium iodide
Tazobactam sodium Peroxyacetic acid 3-Amino-5-mercapto-1,2,4-triazole Potassium permanganate Vinyl acetate
phenylhydrazone Ammonium acetate Celite
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Preparation Products

Tazobactam acid Suppliers

Global( 340)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Nectar Lifesciences Ltd +91-9357244445 +91-9357244445 Punjab, India 29 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
MANGALAM DRUGS AND ORGANICS LIMITED 08147509329 Uttar Pradesh, India 50 58 Inquiry
OCEAN TRADING CORPORATION +91(22) 24921669 New Delhi, India 6211 58 Inquiry
Hpets Biotech Company (Chongqing) Co.,ltd +8613340353813 China 26 58 Inquiry
Hebei Mojin Biotechnology Co., Ltd +8613288715578 China 12452 58 Inquiry
Supplier Advantage
Nectar Lifesciences Ltd 58
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
TCI Chemicals (India) Pvt. Ltd. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
SynZeal Research Pvt Ltd 58
MANGALAM DRUGS AND ORGANICS LIMITED 58
OCEAN TRADING CORPORATION 58
Hpets Biotech Company (Chongqing) Co.,ltd 58
Hebei Mojin Biotechnology Co., Ltd 58

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4,4-dioxide,(2s-(2-alpha,3-beta,5-alpha))--triazol-1-ylmethyl) cl298741 ytr83oh tazobactam acid TAZOBACTAN ACID (2S,3S,5R)-3-METHYL-4,4,7-TRIOXO-3-[1,2,3]TRIAZOL-1-YLMETHYL-4LAMBDA6-THIA-1-AZA-BICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID Tazobactam, Free acid 2b-[(1,2,3-triazol-1-yl)methyl]-2a-methylpenam-3a-carboxylic acid 1,1-dioxide CL-298741：YTR-830 YTR-830H (2s,3s,5r)-3-methyl-4,4,7-trioxo-3-(1h-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Tazobactam,Tazobactanacid Tazobactum (Free acid) [2S-(2α，3β，5α)]-3-Methyl-7-oxo-3-(1H-1，2，3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4，4-dioxide (2S,3S,5R)-2-Carboxy-3-methyl-3-[(1H-1,2,3-triazol-1-yl)methyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane4,4-dioxide Tazobactam (200 mg) (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-(1H-1,2,3-triazol-1-ylMethyl)-4$l^{6}-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Tazobactam acid (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid [2S-(2α,3β,5α)]-3-Methyl-7-oxo-3-(1H,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptan-2-carbonsure-4,4-dioxid (2S,3S,5R)-3-METHYL-7-OXO-3-(1H-1,2,3-TRIAZOLE-1-YLMETHYL)-4- THIA-1-AZABICYCLO(3.2.0)HEPTANE-2-CARBOXYLIC ACID 4,4-DIOXIDE Tarobactam acid Tazobactamum 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, (2S,3S,5R)- (2S,3S,5R)-3-((1H-1,2,3-Triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide Tazobactam acid USP/EP/BP Tazobactam (CL-298741 Tazobactam acidQ: What is Tazobactam acid Q: What is the CAS Number of Tazobactam acid Q: What is the storage condition of Tazobactam acid Q: What are the applications of Tazobactam acid Tazobactam (1643383) 5-benzodioxepin-3(4H)-one 7-Methyl-2H-1 TAZOBACTAM (2S,3S,5R)-3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide He (the temple (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Tazobactamum|||Tazobactam acid|||YTR-830H|||CL-298741 89786-04-9 C10H12N4O5S TAZOCIN Amino Acid Derivatives Peptide Synthesis/Antibiotics pharmaceutical