Coumaphos | 56-72-4

Coumaphos Properties

Melting point	95-97oC
Boiling point	449.9±55.0 °C(Predicted)
Density	1.4740
vapor pressure	1.3 x 10^-5 Pa (20 °C)
Flash point	100 °C
storage temp.	APPROX 4°C
solubility	DMSO: Slightly Soluble,Methanol: Slightly Soluble
Water Solubility	1.5 mg l^-1 (20 °C)
form	solid
Merck	13,2584
BRN	327083
Stability	Stable. Combustible. Incompatible with alkalies, strong oxidising agents.
CAS DataBase Reference	56-72-4(CAS DataBase Reference)
NIST Chemistry Reference	Coumaphos(56-72-4)
EPA Substance Registry System	Coumaphos (56-72-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS09

Signal word

Danger

Hazard statements

H300-H311-H410

Precautionary statements

P264-P270-P273-P280-P301+P310-P302+P352+P312

Hazard Codes

T+,N,Xn,F

Risk Statements

21-28-50/53-36-20/21/22-11

Safety Statements

28-36/37-45-60-61-36-26-16

RIDADR

2783

WGK Germany

3

RTECS

GN6300000

HazardClass

6.1(a)

PackingGroup

II

Toxicity

LD50 in female, male rats (mg/kg): 16, 41 orally (Gaines)

NFPA 704

	0
3		0

Coumaphos price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	89260	Coumaphos reference material	56-72-4	50MG	₹12048.23	2022-06-14	Buy
Sigma-Aldrich(India)	45403	Coumaphos PESTANAL?, analytical standard	56-72-4	250MG	₹6538.3	2022-06-14	Buy

Product number	Packaging	Price	Buy
89260	50MG	₹12048.23	Buy
45403	250MG	₹6538.3	Buy

Coumaphos Chemical Properties,Uses,Production

Description

Technical coumaphos is a tan crystalline solid with a slight sulphur odour. It is insoluble in water; slightly soluble in acetone, chloroform, and ethanol; and soluble in organic solvents. Coumaphos when heated undergoes decomposition and releases very toxic fumes of sulphur oxides, phosphorous oxides, and chlorides. It is used for the control of a wide variety of livestock insects, including cattle grubs, screwworms, lice, scabies, flies, and ticks. It is used against ectoparasites, which are insects that live on the outside of host animals such as sheep, goats, horses, pigs, and poultry. Coumaphos is incompatible with alkalis, strong oxidising agents, pyrethroids, and piperonyl butoxide. The U.S. EPA has grouped coumaphos as RUP.

Chemical Properties

coumaphos is a tan crystalline solid with a slight sulfur odor. It is insoluble in water, slightly soluble in acetone, chloroform, and ethanol, and soluble in organic solvents. It is used for the control of a wide variety of livestock insects, including cattle grubs, screwworms, lice, scabies, fl ies, and ticks. It is used against ectoparasites, which are insects that live outside the host animals, such as sheep, goats, horses, pigs, and poultry. Coumaphos is incompatible with pyrethroids and piperonyl butoxide. The US EPA has grouped coumaphos as an RUP. Acute dermal exposures to occupational workers occur during mixing, loading, and application of coumaphos, especially in the livestock dip-vat and hand-held sprayer uses

Uses

Coumaphos is used to control larvae of Diptera and ticks on cattle. It has also recently been used to control Varroa mite in honeybees.

General Description

Slightly brownish crystals with a slight sulfurous odor. Used for the control of a wide variety of livestock insects including cattle grubs, lice, scabies, flies, and ticks; the common ectoparasites of sheep, goats, horse, swine, and poultry as well as for screwworms in all these animals.

Air & Water Reactions

Insoluble in water. Coumaphos hydrolyzes slowly under alkaline conditions.

Reactivity Profile

Organothiophosphates, such as Coumaphos, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. Coumaphos reacts with strong oxidizing agents and alkaline materials.

Hazard

Use may be restricted; cholinesterase inhibitor. Questionable carcinogen.

Health Hazard

Exposures to coumaphos cause signs of poisoning such as diarrhea, drooling, diffi culty in breathing, leg and neck stiffness among occupational workers. Acute inhalation of coumaphos causes headaches, dizziness, and incoordination. Moderate poisoning causes muscle twitching and vomiting while severe poisoning leads to fever, toxic psychosis, lung edema, and high blood pressure. Repeated exposures cause irritability, confusion, headache, speech diffi culties, effects on memory concentration, disorientation, severe depressions, sleepwalking, and drowsiness or insomnia among occupational workers. Coumaphos has been classifi ed as non-carcinogenic to humans

Fire Hazard

When heated to decomposition, Coumaphos emits very toxic fumes of sulfur oxides, phosphorus oxides, and chlorides. Incompatible with piperonyl butoxide. Stable in water.

Agricultural Uses

Insecticide, Nematocide; Veterinary medication: The U.S. EPA classifies the formulations 11.6% EC and 42% flowable concentrate end-use products as Restricted Use Pesticides (RUPs) because they pose a hazard of acute poisoning from ingestion. Coumaphos is an insecticide/acaricide used to control a wide variety of liver stock insects including cattle grubs, fleeceworms, lice scabies, flies, and ticks; the common ectoparasites of beef cattle, dairy cows, sheep, goats, horse, swine, and poultry as well as for screw worms in all these animals. The USDA uses coumaphos in dip vats along the U.S.-Texas border to control ticks that carry Texas Cattle Fever. It is added to cattle and poultry feed to control the development of fly larvae that breed in manure. It has applications in beekeeping.

Trade name

AGRIDIP®; ASUNTOL®; AZUNTHOL®; BAY® 21/199; BAYER® 21/199; BAYMIX®; BAYMIX® 50; CHECKMITE®; CO-RAL®[C]; DELICE®; MELDANE®; MELDONE®; MUSCATOX®; NEGASHUNT®; DIOLICE®; RESITOX®; SUNTOL®; UMBETHION®

Safety Profile

Poison by ingestion, sktn contact, inhalation, and intraperitoneal routes. Mutation data reported. When heated to decomposition, it emits very toxic fumes of SOx, PO,, and Cl-. See also COUMARIN.

Potential Exposure

A potential danger to those involved in the manufacture, formulation, and application of this material which is used for control of a wide variety of livestock insects including cattle grubs, lice scabies, flies, and ticks; the common ectoparasites of sheep, goats, horse, swine, and poultry; as well as for screw worms in all these animals.

Carcinogenicity

There was no evidence of carcinogenicity at any dose in rats fed diets that contained 1, 5, or 25 ppm coumaphos (0.05, 0.25, or 1.22 mg/kg/day (males); 0.07, 0.36, or 1.70 mg/kg/day (females)) for 2 years . There was no evidence of carcinogenicity in another study when rats were given diets that contained 10 or 20 ppm coumaphos for 103 weeks .

Metabolic pathway

By UV irradiation of coumaphos in solutions, three dimeric products are isolated and identified as the head-to-tail anti-dimer, its oxidation product, and the head-to-tail syn-dimer.

Metabolism

Degradation occurs rapidly in the liver of the cow and rat. The principal metabolite excreted in urine is diethyl hydrogen phosphorothioate. Deethylation products are also found in lesser amounts. Photolytic DT₅₀ on soil surface is 23.8 d.

Shipping

UN2783 Organo phosphorus pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous material. UN3018 Organophosphorus pesticides, liquid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Incompatibilities

Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrideds and active metals. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. Keep away from piperonyl butoxide, oxidizers, strong bases, water, and heat

Waste Disposal

Coumaphos can be decomposed by heating with concentrated alkali. Large amounts should be incinerated in a unit equipped with effluent gas scrubbing. Do not discharge into drains or sewers. Dispose of waste material as hazardous waste using a licensed disposal contractor to an approved landfill. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (>=100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration with effluent gas scrubbing is recommended. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office

Coumaphos Preparation Products And Raw materials

Raw materials

3-CHLORO-4-METHYL-7-HYDROXYCOUNMARIN Ethyl acetoacetate CI Acetyl chloride Potassium carbonate

2-Butanone Resorcinol 3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN

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Preparation Products

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THIOPHOSPHORYL CHLORIDE Terbufos Coumaphos

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3-Chloro-4-methyl-7-coumarinyl diethyl phosphorothioate 3-chloro-4-methyl-7-coumarinyldiethylphosphorothioate 3-Chloro-4-methyl-7-hydroxycoumarin diethyl thiophosphoric acid ester 3-chloro-4-methyl-7-hydroxycoumarindiethylthiophosphoricacidester 3-Chloro-4-methylumbelliferone o-ester with O,O-diethyl phosphorothioate 3-chloro-4-methylumbelliferoneo-esterwitho,o-diethylphosphorothioate 3-chloro-7-diethoxyphosphinothioyloxy-4-methylcoumarin 3-Chloro-7-hydroxy-4-methyl-coumarin O,O-diethyl phosphorothioate 3-Chloro-7-hydroxy-4-methyl-coumarin O-ester with O,O-diethyl phosphorothioate 3-chloro-7-hydroxy-4-methyl-coumarino,o-diethylphosphorothioate 3-chloro-7-hydroxy-4-methyl-coumarino-esterwitho,o-diethylphosphorothioat 3-chloro-7-hydroxy-4-methylcoumarino-esterwitho,o-diethylphosphorothioate Agridip Azunthol BAY 21/199 Diethyl 3-chloro-4-methylumbelliferyl thionophosphate Diethyl thiophosphoric acid ester of 3-chloro-4-methyl-7-hydroxycoumarin diethyl3-chloro-4-methylumbelliferylthionophosphate diethyl-o(3-chloro-4-methyl-7-coumarinyl)phosphorothioate diethylthiophosphoricacidesterof3-chloro-4-methyl-7-hydroxycoumarin Diolice ENT 17,957 ent17,957 epapesticidecode026501. Meldane Meldone Muscatox NCI-C08662 Negashunt O,O-Diethyl-O-(3-chloro-4-methyl-cumarin-7-yl)monothiofosfaat o,o-diethylo-(3-chloro-4-methylumbelliferone)thiophosphate o,o-diethylo-(3-chloro-4-methylumbelliferyl)phosphorothioate O,O-Dietil-O-(3-chloro-4-metil-cumarin-7-il-monotiofosfato) O,O-Dietil-O-(3-cloro-4-metil-cumarin-7-il-monotiofosfato) o-3-chloro-4-methyl-2-oxo-2h-chromen-7-yl-o,o-diethylphosphorothioate O-3-Chloro-4-methyl-7-coumarinyl O,O-diethyl phosphorothioate o-3-chloro-4-methyl-7-coumarinylo,o-diethylphosphorothioate o-3-chloro-4-methylcoumarin-7-ylo,o-diethylphosphorothioate oms485 Phosphorothioic acid, O-(3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl) O,O-diethyl ester Phosphorothioic acid, O,O-diethyl ester, O-ester with 3-chloro-7-hydroxy-4-methylcoumarin Phosphorothioicacid,esters,O-(3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl)O,O-diethylester phosphorothioicacid,o-(3-chloro-4-methyl-2-oxo-2h-1-benzopyran-7-yl)o,o-diet phosphorothioicacid,O-(3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl)O,O-diethylester phosphorothioicacid,o,o-diethylester,o-esterwith3-chloro-7-hydroxy-4-me phosphorothioicacid,o,o-diethylester,o-esterwith3-chloro-7-hydroxy-4-meth Resistox Resitox Resitox 794 Suntol Thiophosphate de O,O-diethyle et de O-(3-chloro-4-methyl-7-coumarinyle) thiophosphatedeo,o-diethyleetdeo-(3-chloro-4-methyl-7-coumarinyle) thiophosphatedeo,o-diethyleetdeo-(3-chloro-4-methyl-7-coumarinyle)(french thylcoumarin umbelliferone,3-chloro-4-methyl-,O,O-diethylphosphorothioate Umbethion coumaphos(bsi,iso,esa,ban) 3-CHLOR-7-HYDROXY-4-METHYL-COUMARIN-O,O-DIETHYLPHOSPHOROT.