BML-210
- CAS No.
- 537034-17-6
- Chemical Name:
- BML-210
- Synonyms
- CS-2301;BML-210;CAY10433;BML210, >98%;BML-210, (BML210;BML-210(CAY10433);BML-210 >=98% (HPLC), powder;N-(2-AMINOPHENYL)-N'-PHENYL-OCTANEDIAMIDE;N1-(2-aminophenyl)-N8-phenyl-octanediamide;Octanediamide, N1-(2-aminophenyl)-N8-phenyl-
- CBNumber:
- CB8254476
- Molecular Formula:
- C20H25N3O2
- Molecular Weight:
- 339.43
- MOL File:
- 537034-17-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/18 11:31:13
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H361-H372-H410 |
| Precautionary statements | P201-P264-P280-P301+P330+P331-P312 |
| WGK Germany | 3 |
BML-210 price More Price(2)
BML-210 Chemical Properties,Uses,Production
Description
Inhibition of histone deacetylase (HDAC) enzymes by compounds such as trichostatin A can have wide ranging effects in cancer, cell differentiation, and other aspects of gene expression regulation. BML-210 is a small molecule inhibitor of HDAC with an IC50 value of 30 μM when tested in HeLa cell nuclear extracts using 200 μM acetylated fluorometric substrate (substrate available in Cayman’s HDAC Activity and Inhibitor Screening Assay Kits -
Definition
ChEBI: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and 1,2-diaminobenzene.
Biochem/physiol Actions
BML-210 is a synthetic benzamide and is a potential tumor inhibitor. It is used as a therapeutic agent to treat promyelocytic leukemia. In human leukemia cell lines (NB4, HL-60, THP-1, and K562), BML-210 modulates histone deacetylase and promotes apoptosis. BML-210 favors frataxin expression in neurodegenerative disease Friedreich′s ataxia (FRDA). It interacts with myocyte enhancer factor-2 (MEF2) via hydrogen-bonding and prevents histone deacetylase 4 (HDAC4) binding.
BML-210 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | China | 12308 | 58 | Inquiry |
| Shanghai Zeye Biotechnology Co., Ltd. | 021-61998551 13122364865 | China | 9771 | 58 | Inquiry |