Polymyxin B sulfate
- CAS No.
- 1405-20-5
- Chemical Name:
- Polymyxin B sulfate
- Synonyms
- POLYMYXIN B;POLYMYXIN B SULPHATE;POLYMIXIN B SULFATE;AEROSPORIN;POLYMIXIN B SULPHATE;polymyxin B sulfate usp;Polymyxin B sulfate for microbiological assay;N-[3-AMino-1-[[1-[[3-aMino-1-[[6,9,18-tris(2-aMinoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-Methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbaMoyl]propyl]carbaMoyl]-2-hydroxy-propyl]carbaMoyl]pro;Poly-RX;APPLISORB
- CBNumber:
- CB8666707
- Molecular Formula:
- C56H100N16O17S
- Molecular Weight:
- 1301.56
- MOL File:
- 1405-20-5.mol
- Modify Date:
- 2024/8/15 13:22:53
| Melting point | 217-220°C (dec.) |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL |
| form | powder |
| pka | pKa 8.9 (Uncertain) |
| color | colorless or slightly yellow |
| PH | pH (10g/L, 25℃) : 4.5～7.0 |
| optical activity | [α]/D 20/D (Rotation: -2.3 +/- 0.2 degrees) |
| Water Solubility | Soluble in water at 50mg/ml/n |
| Merck | 14,7573 |
| Stability | Hygroscopic |
| InChIKey | HFMDLUQUEXNBOP-UHFFFAOYSA-N |
| LogP | -6.361 (est) |
| CAS DataBase Reference | 1405-20-5(CAS DataBase Reference) |
| EPA Substance Registry System | Polymixin B sulfate (1405-20-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TR1150000 | |||||||||
| F | 3-8-10 | |||||||||
| HS Code | 2941 90 00 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| Toxicity | dog,LDLo,intracrebral,320ug/kg (0.32mg/kg),BEHAVIORAL: COMA,British Journal of Pharmacology and Chemotherapy. Vol. 23, Pg. 552, 1964. | |||||||||
| NFPA 704 |
|
Polymyxin B sulfate price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P1004 | Polymyxin B sulfate salt | 1405-20-5 | 1000000UNITS | ₹4665.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1595 | Polymyxin B Sulfate Pharmaceutical Secondary Standard; Certified Reference Material | 1405-20-5 | 500MG | ₹8692.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P1004 | Polymyxin B sulfate salt | 1405-20-5 | 5000000UNITS | ₹10153.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P4932 | Polymyxin B sulfate salt powder, BioReagent, suitable for cell culture | 1405-20-5 | 1000000UNITS | ₹6083.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P1004 | Polymyxin B sulfate salt | 1405-20-5 | 10000000UNITS | ₹13607.03 | 2022-06-14 | Buy |
Polymyxin B sulfate Chemical Properties,Uses,Production
Description
The polymyxins are cationic peptides originally isolated from B. polymyxa. They bind and kill Gram-
Chemical Properties
White Solid
Uses
Polymyxin B sulfate is used as topical antibiotic agent, often used in combination with neomycin; products include ointments, creams, eye, and ear drops.
Indications
Polymyxin B is one of a group of cyclic polypeptides elaborated by Bacillus polymyxa. The drug is a surface-active agent. It is thought to alter the lipoprotein membrane of bacteria so that it no longer functions as an effective barrier, thereby allowing the cell contents to escape. Polymyxin B is effective against Pseudomonas, E. coli, and other gram-negative bacteria except the Proteus and Serratia species. It has little effect on gram-positive organisms.
General Description
Polymyxin (Aerosporin) was discovered in 1947 almost simultaneouslyin three separate laboratories in the UnitedStates and Great Britain. As often happens whensimilar discoveries are made in widely separated laboratories,differences in nomenclature, referring to both theantibiotic-producing organism and the antibiotic itself, appearedin references to the polymyxins. Because the organismsfirst designated as Bacillus polymyxa and B.aerosporus Greer were found to be identical species, thename B. polymyxa is used to refer to all of the strains thatproduce the closely related polypeptides called polymyxins.Other organisms (e.g., see “Colistin” later) also producepolymyxins. Identified so far are polymyxins A, B1,B2, C, D1, D2, M, colistin A (polymyxin E1), colistin B(polymyxin E2), circulins A and B, and polypeptin. Theknown structures of this group and their properties havebeen reviewed by Vogler and Studer. Of these,polymyxin B as the sulfate usually is used in medicine because,when used systemically, it causes less kidney damagethan the others. Polymyxin B sulfate is a nearly odorless, white to buff powder. It is freely soluble in water and slightly soluble in alcohol.
Clinical Use
Polymyxin B is produced by fermentation of Bacillus polymyxa. It is separated from a mixture of related cyclic peptides and is primarily active against Gram-negative microorganisms. It apparently binds to phosphate groups in bacterial cytoplasmic membranes and disrupts their integrity. It is used IM or IV as a sulfate salt to treat serious urinary tract infections, meningitis, and septicemia, primarily caused by Pseudomonas aeruginosa, but some other Gram-negative bacteria also will respond. Irrigation of the urinary bladder with solutions of polymyxin B sulfate is employed as well by some to reduce the incidence of infections subsequent to installation of indwelling catheters. Additionally, it is used ophthalmically to treat infections by P. aeruginosa. When given parenterally, the drug is neuro- and nephrotoxic and, therefore, is employed only after other drugs have failed.
Polymyxin B sulfate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| AnalyticsStanza Inc | +91-7032031309 +91-7032031309 | Hyderabad, India | 227 | 58 | Inquiry |
| Sumar Biotech LLP | +91-7984183709 +91-9824575381 | Gujarat, India | 22 | 58 | Inquiry |
| Medi Pharma Drug House | +919930911911 | Mumbai, India | 143 | 58 | Inquiry |
| PROTECH TELELINKS | +91-8571891912 +91-9855060837 | Himachal Pradesh, India | 62 | 58 | Inquiry |
| Ruskin Chemipharm | 09820476680 | Mumbai, India | 22 | 58 | Inquiry |
| Oxford laboratories | +91 250 239 0032 | Maharashtra, India | 652 | 58 | Inquiry |
| K.Sevantilal & Co. | 91-22-66342925 | Maharashtra, India | 17 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Add Biotec | 91-22-26731400 | Maharashtra, India | 49 | 58 | Inquiry |
| Scientific OEM | +91-22- 2343 7546 / 2341 3094 | New Delhi, India | 1996 | 38 | Inquiry |
| Supplier | Advantage |
|---|---|
| AnalyticsStanza Inc | 58 |
| Sumar Biotech LLP | 58 |
| Medi Pharma Drug House | 58 |
| PROTECH TELELINKS | 58 |
| Ruskin Chemipharm | 58 |
| Oxford laboratories | 58 |
| K.Sevantilal & Co. | 58 |
| Clearsynth Labs | 58 |
| Add Biotec | 58 |
| Scientific OEM | 38 |
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