Nafcillin sodium salt monohydrate
- CAS No.
- 7177-50-6
- Chemical Name:
- Nafcillin sodium salt monohydrate
- Synonyms
- nafcillin sodium;Nafcillin sodium hydrate;Nafcillin sodium monohydrate;D00928;CL 8491;Unipen (tn);Naproxillin sodium;Emorfazone Impurity 1;Nafcillin sodium (usp);NAFCILLINSODIUMSTERILE
- CBNumber:
- CB8769646
- Molecular Formula:
- C21H25N2NaO6S
- Molecular Weight:
- 456.49
- MOL File:
- 7177-50-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:37
| storage temp. | 2-8°C |
|---|---|
| solubility | H2O: soluble50mg/mL |
| form | A crystalline solid |
| color | White to off-white |
| CAS DataBase Reference | 7177-50-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H317-H319-H334-H335 | |||||||||
| Precautionary statements | P261-P280-P284-P304+P340-P305+P351+P338-P342+P311 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 36/37/38-42/43 | |||||||||
| Safety Statements | 26-36-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29411099 | |||||||||
| NFPA 704 |
|
Nafcillin sodium salt monohydrate price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR1704 | Nafcillin Sodium Pharmaceutical Secondary Standard; Certified Reference Material | 7177-50-6 | 1G | ₹15966.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N3269 | Nafcillin sodium salt monohydrate | 7177-50-6 | 5G | ₹15468.93 | 2022-06-14 | Buy |
Nafcillin sodium salt monohydrate Chemical Properties,Uses,Production
Uses
Nafcillin sodium salt monohydrate is an antibiotic resistant to beta-lactamase.
Clinical Use
Nafcillin sodium, 6-(2-ethoxy-1-naphthyl)penicillin sodium(Unipen), is another semisynthetic penicillin that resultedfrom the search for penicillinase-resistant compounds. Likemethicillin, nafcillin has substituents in positions ortho tothe point of attachment of the aromatic ring to the carboxamidegroup of penicillin. No doubt, the ethoxy group andthe second ring of the naphthalene group play steric roles instabilizing nafcillin against penicillinase. Very similar structureshave been reported to produce similar results in somesubstituted 2-biphenylpenicillins.
Unlike methicillin, nafcillin is stable enough in acid topermit its use by oral administration. When it is givenorally, its absorption is somewhat slow and incomplete,but satisfactory plasma levels may be achieved in about1 hour. Relatively small amounts are excreted throughthe kidneys; most is excreted in the bile. Even thoughsome cyclic reabsorption from the gut may occur, nafcillingiven orally should be readministered every 4 to 6 hours.This salt is readily soluble in water and may be administeredintramuscularly or intravenously to obtain highplasma concentrations quickly for the treatment of seriousinfections.
Nafcillin sodium may be used in infections causedsolely by penicillin G-resistant staphylococci or whenstreptococci are present also. Although it is recommendedthat it be used exclusively for such resistant infections, nafcillin is also effective against pneumococci and groupA -hemolytic streptococci. Because, like other penicillins,it may cause allergic side effects, it should be administeredwith care.
Nafcillin sodium salt monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| JA Sterile Pvt Ltd | +91-9427679998 +91-9427679998 | Gujarat, India | 21 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| AUROBINDO PHARMA LTD | +91 (40) 6672 1200 | New Delhi, India | 209 | 58 | Inquiry |
| Medilink Pharmachem | +91 (79) 3007-0133 | New Delhi, India | 424 | 50 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29899 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49403 | 58 | Inquiry |
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