2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]-
![2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- Structure](CAS/GIF/194423-06-8.gif)
- CAS No.
- 194423-06-8
- Chemical Name:
- 2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]-
- Synonyms
- 785;CL-387;EKB 785;CS-1630;-387785;CL-38875;WAY-EKI 785;CL-387785, >=98%;EKI-785 CL-38875;CL-387785 (EKI-785)
- CBNumber:
- CB92626313
- Molecular Formula:
- C18H13BrN4O
- Molecular Weight:
- 381.23
- MOL File:
- 194423-06-8.mol
- Modify Date:
- 2023/6/8 17:06:36
| Melting point | 276 °C |
|---|---|
| Density | 1.577±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | insoluble in EtOH; insoluble in H2O; ≥16.85 mg/mL in DMSO |
| pka | 9.84±0.43(Predicted) |
| form | Off-white to yellow solid. |
| color | White to Orange to Green |
2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 233100 | CL-387,785 - CAS 194423-06-8 - Calbiochem A cell-permeable and irreversible inhibitor of EGF-receptor (EGFR) kinase activity in vivo (IC?? = 250-490 pM) as well as EGF-stimulated autophosphory | 194423-06-8 | 1MG | ₹17860 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C3575 | CL-387785 | 194423-06-8 | 25MG | ₹8000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C3575 | CL-387785 | 194423-06-8 | 100MG | ₹18600 | 2022-05-26 | Buy |
2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- Chemical Properties,Uses,Production
Description
Overactivity of epidermal growth factor receptor (EGFR) tyrosine kinase activity has been associated with a number of cancers. CL 387,785 is a potent, irreversible inhibitor of EGFR kinase activity (IC50 = 370 pM). It blocks EGF-stimulated autophosphorylation of receptors in cells (IC50 = 5 nM) and halts cell cycling in cells that overexpress EGFR or c-ErbB2 (IC50s = 31-125 nM). CL 387,785 profoundly blocks the growth of EGFR-overexpressing tumors in nude mice when given orally at 80 mg/kg/day for 10 days.
Uses
CL-387785 (EKI-785) is an irreversible and selective EGFR inhibitor showing activity against mutations of the receptor. Potential therapeutic against various type of cancer, including lung cancer.
Definition
ChEBI: A member of the class of quinazolines that is 4,6-diaminoquinazoine in which the one of the hydrogens attached to the amino group at position 4 has been replaced by a m-bromophenyl group while one of the hydrogens attached to the amino group a position 6 has been replaced by a but-2-ynoyl group.
2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | China | 5738 | 58 | Inquiry |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | China | 694 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24607 | 58 | Inquiry |