2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]-
![2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- Structure](/CAS/GIF/194423-06-8.gif)
|
- ₹8000 - ₹18600
- Product name: 2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]-
- CAS: 194423-06-8
- MF: C18H13BrN4O
- MW: 381.23
- EINECS:
- MDL Number:MFCD02179194
- Synonyms:CL-387785 (EKI-785);N-(4-(3-bromophenylamino)quinazolin-6-yl)but-2-ynamide;N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]-2-ButynaMide CL-387785;2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]-;CL-387785, >=98%;CL-38875;EKB 785;WAY-EKI 785
3 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 1MG
- 25MG
- 100MG
- ManufacturerTCI Chemicals (India)
- Product numberC3575
- Product descriptionCL-387785
- Packaging25MG
- Price₹8000
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberC3575
- Product descriptionCL-387785
- Packaging100MG
- Price₹18600
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number233100
- Product descriptionCL-387,785 - CAS 194423-06-8 - Calbiochem A cell-permeable and irreversible inhibitor of EGF-receptor (EGFR) kinase activity in vivo (IC?? = 250-490 pM) as well as EGF-stimulated autophosphory
- Packaging1MG
- Price₹17860
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | C3575 | CL-387785 | 25MG | ₹8000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C3575 | CL-387785 | 100MG | ₹18600 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | 233100 | CL-387,785 - CAS 194423-06-8 - Calbiochem A cell-permeable and irreversible inhibitor of EGF-receptor (EGFR) kinase activity in vivo (IC?? = 250-490 pM) as well as EGF-stimulated autophosphory | 1MG | ₹17860 | 2022-06-14 | Buy |
Properties
Melting point :276 °C
Density :1.577±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :insoluble in EtOH; insoluble in H2O; ≥16.85 mg/mL in DMSO
pka :9.84±0.43(Predicted)
form :Off-white to yellow solid.
color :White to Orange to Green
Density :1.577±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :insoluble in EtOH; insoluble in H2O; ≥16.85 mg/mL in DMSO
pka :9.84±0.43(Predicted)
form :Off-white to yellow solid.
color :White to Orange to Green
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
Overactivity of epidermal growth factor receptor (EGFR) tyrosine kinase activity has been associated with a number of cancers. CL-387785 is a potent, irreversible inhibitor of EGFR kinase activity (IC50 = 370 pM). It blocks EGF-stimulated autophosphorylation of receptors in cells (IC50 = 5 nM) and halts cell cycling in cells that overexpress EGFR or c-ErbB2 (IC50s = 31-125 nM). CL-387785 profoundly blocks the growth of EGFR-overexpressing tumors in nude mice when given orally at 80 mg/kg/day for 10 days.More related product prices
Doxorubicin hydrochloride Crenolanib AZD-1208 Ilomastat L-4-THIAZOLYLALANINE 4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide PF-04929113 IXABEPILONE OTAVA-BB 1115529 Tariquidar Esomeprazole magnesium ZLN005 BLU 9931 1 NM-PP1 (-)-Blebbistatin Finasteride Canertinib TYRPHOSTIN A25Related product price
- Doxorubicin hydrochloride
₹4491-89190 - Ilomastat
₹10670-59569.98 - OTAVA-BB 1115529
₹10684.28-43061.85
![N-[4-(3-bromoanilino)quinazolin-6-yl]but-2-ynamide](https://img.chemicalbook.com/ProductImageEN/2019-12/small/6071f2ba-f93d-486f-9cdb-74f52151c90f.png){kind=small}