ChemicalBook > Product Catalog >Chemical Reagents >Organic reagents >Sulfonates / Sulfinates salts >Atracurium besylate
Atracurium besylate
- CAS No.
- 64228-81-5
- Chemical Name:
- Atracurium besylate
- Synonyms
- ATRACURIUM BESILATE;Atracurim besylate;51W89;BW-33A;Tracur;TRACRIUM;51W-89：Nimbex;Wellcome 33A74;Atracurium BesyL;ATRACURIUM BESYLAT
- CBNumber:
- CB9379882
- Molecular Formula:
- C65H82N2O18S2
- Molecular Weight:
- 1243.48
- MOL File:
- 64228-81-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/28 7:28:55
| Melting point | 85-90°C |
|---|---|
| storage temp. | Inert atmosphere,2-8°C |
| solubility | H2O: ~27 mg/mL |
| form | powder |
| color | white |
| InChIKey | YXSLJKQTIDHPOT-UHFFFAOYSA-N |
| CAS DataBase Reference | 64228-81-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29334900 | |||||||||
| NFPA 704 |
|
Atracurium besylate Chemical Properties,Uses,Production
Chemical Properties
White to yellowish-white powder, slightly hygroscopic
Uses
A neuromuscular blocking agent
Definition
ChEBI: The bisbenzenesulfonate salt of atracurium.
Biological Functions
Atracurium besylate (Tracrium) is a benzylisoquinolinium compound like d-tubocurarine. Its actions are similar to those of d-tubocurarine, but its duration of action is shorter (45 minutes) because of spontaneous degradation of the molecule (Hofmann elimination). Because of this, atracurium is useful in patients with low or atypical plasma cholinesterase and in patients with renal or hepatic impairment.
General Description
Atracurium besylate, 2-(2-carboxyethyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinolinium benzenesulfonate pentamethyleneester (Tracrium), is a nondepolarizing neuromuscular blockingagent that is approximately 2.5 times more potent thand-tubocurarine. Its duration of action (half-life, 0.33 hours)is much shorter than that of d-tubocurarine.
Clinical Use
Atracurium Besylate is metabolized rapidly and nonenzymatically to yield laudanosineand a smaller quaternary compound ,which do not have neuromuscular blocking activity. In vitroexperiments show that atracurium besylate breaks down atpH 7.4 and 37°C by a Hoffman elimination reaction.Atracurium besylate undergoes enzymatic decompositionof its ester function to yield an inactive quaternary alcoholand quaternary acid. AChE inhibitors such as neostigmine,edrophonium, and pyridostigmine antagonize paralysis byatracurium besylate.
Atracurium besylate Preparation Products And Raw materials
Raw materials
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- What is Atracurium Besylate Injection
- Atracurium Besylate Injection is a clear, colorless, or faintly yellow, sterile solution for injection. Each mL contains 10 mg....
- Apr 15，2024
64228-81-5(Atracurium besylate )Related Search:
BW-33A
2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-isoquinolinium dibenzenesulfonate
2，2’-[1，5-Pentanediylbis[oxy(3-oxcr3，1-propanediyl)]]bis[1-[(3，4-dimethoxyphenyl)methyl]-1，2，3，4-tetrahydro-6，7-dimethoxy-2-methylisoquinolinium]dibenzenesulfonate
51W-89：Nimbex
Atraeurium Besylate
Cisatracudum Besylate
BW-33A, Tracrium, 2,2μ-[1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium]dibenzenesulfonate
Isoquinolinium, 2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, dibenzenesulfonate
Pentamethylen bis(3-(1,2,3,4-tetrahydro-6,7-dimethoxy-1-(3,4-dimethoxybenzyl)-2-methyl-2-isochinolyl)propionat)bis(benzolsulfonat)
Atracurium besylate,2,2′-[1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium]dibenzenesulfonate, BW-33A, Tracrium
Atracurium Besylate (100 mg)
2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)meth
2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-Isoquinolinium, benzenesulfonate (1:2)
AtracuriuM Besilete
(1R,2R)-1-[(3,4-diMethoxyphenyl)Methyl]-2-(3-{[5-({3-[(1R,2R)-1-[(3,4-diMethoxyphenyl)Methyl]-6,7-diMethoxy-2-Methyl-1,2,3,4-tetrahydroisoquinolin-2-iuM-2-yl]propanoyl}oxy)pentyl]oxy}-3-oxopropyl)-6,7-diMethoxy-2-Methyl-1,2,3,4-tetrahydroisoquinolin-2-iuM
AtracuriuM besylate (TracriuM)
51W89
Atracurium besylate, >=98%
Atracurium Besylate (mixture of isomers)
2,2'-[1,5-PENTANEDIYLBIS[OXY(3-OXO-3,1-PROPANEDIYL)]]BIS[1-[3,4-DIMETHOXYPHENYL)METHYL]-1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-2-METHYLISOQUINOLINIUM]DIBENZENESULFONATE
TRACRIUM
ATRACURIUM BESILATE INJECTION
AtracuriumBesylate(DMF)
CisatracuriumBesilete
Atracurim besylate Bp
2,2'-[1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-isoquinolinium Benzenesulfonate
Atracurium Dibesylate
Tracur
Wellcome 33A74
ATRACURIUM BESYLAT
Atracuricum Besilate
ATRACURIUM BESYLATE EP/BP
AttracuriumBesylate
CIS-ATRACURIUM BESYLETE
ATRICURIUM BESYLATE
ATRACURIUMBESYLATEUSP
tracurium Besylate
3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoic acid 5-[3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydr
Atracurium besylate, 98%, a neuromuscular blocking agent
Atracurium Besylate (mixture of isomers)>
Atracurium for impurity F identification CRS
Atracurium besilate CRS
Atracurium Besylate,99%
Atracurium besylate, a neuromuscular blocking agent
Atracurium BesyL
Mixture of the cis-cis, cis-trans and trans-trans isomers of 2,2\\\\\\\'-[Pentane-1,5-diylbis[oxy(3-oxopropane-1,3-diyl)]]bis[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium] dibenzenesulfonate
2,2'-((Pentane-1,5-diylbis(oxy))bis(3-oxopropane-3,1-diyl))bis(1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium) benzenesulfonate
Atracurium Besylate (BW-33A)
Atracurium besilate (Y0000424)
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