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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >TGF-beta / Smad >PKC inhibitor >RO-31-8220

RO-31-8220

RO-31-8220 Structure
CAS No.
138489-18-6
Chemical Name:
RO-31-8220
Synonyms
CS-1132;RO-31-8220;Ro31-8220MsOH;Ro 31-8220 Mesylat;Ro 31-8220/Ro318220;RO-31-8220 USP/EP/BP;BisindolylMaleiMide IX Mesylate;BISINDOLYLMALEIMIDE IX, METHANESULFONATE;Ro-31-8220 - CAS 138489-18-6 - Calbiochem;Bisindolylmaleimide IX (Ro 31-8220 Mesylate)
CBNumber:
CB9711637
Molecular Formula:
C25H23N5O2S
Molecular Weight:
457.55
MOL File:
138489-18-6.mol
MSDS File:
SDS
Modify Date:
2024/11/17 8:48:38
Request For Quotation

RO-31-8220 Properties

storage temp. 2-8°C
solubility DMSO:52.77(Max Conc. mg/mL);95.31(Max Conc. mM)
DMF:25.0(Max Conc. mg/mL);45.15(Max Conc. mM)
DMF:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.18(Max Conc. mM)
Ethanol:2.77(Max Conc. mg/mL);5.0(Max Conc. mM)
form Red solid
color Red

SAFETY

Risk and Safety Statements

HS Code  2933790090

RO-31-8220 price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) R136 Ro 31-8220 methanesulfonate salt solid 138489-18-6 1MG ₹18380.85 2022-06-14 Buy
Sigma-Aldrich(India) R136 Ro 31-8220 methanesulfonate salt solid 138489-18-6 5MG ₹73296.08 2022-06-14 Buy
Sigma-Aldrich(India) 557520 Ro-31-8220 - CAS 138489-18-6 - Calbiochem A cell-permeable, reversible, competitive, and selective inhibitor of protein kinase C (PKC; IC?? = 10 nM) over CaM kinase II (IC?? = 17 μM) and prote 138489-18-6 500μG ₹14880.01 2022-06-14 Buy
Product number Packaging Price Buy
R136 1MG ₹18380.85 Buy
R136 5MG ₹73296.08 Buy
557520 500μG ₹14880.01 Buy

RO-31-8220 Chemical Properties,Uses,Production

Uses

Ro 31-8220 Mesylate is a protein kinase C (PKC) inhibitor.

General Description

Ro 31-8220 is a bisindolylmaleimide derivative of staurosporine. Ro 31-8220 blocks MAP kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression and stimulates Jun N-terminal Kinase (JNK1). It has immunosuppressive properties.

Biochem/physiol Actions

Inhibitor of GRK-5 (G protein-coupled receptor kinase); PKC (protein kinase C); MAPKAP kinase 1β and p70 S6 kinase.

RO-31-8220 Preparation Products And Raw materials

Raw materials

Preparation Products

RO-31-8220 Suppliers

Global( 136)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32951 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29811 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32080 58 Inquiry
Hubei Ipure Biology Co., Ltd +8613367258412 China 10319 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 22883 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10473 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6391 58 Inquiry
TargetMol Chemicals Inc. United States 38470 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
TargetMol Chemicals Inc. 58
Hubei Ipure Biology Co., Ltd 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
TargetMol Chemicals Inc. 58

RO-31-8220 Spectrum

RO-31-8220(138489-18-6)1HNMR

138489-18-6(RO-31-8220)Related Search:

GO 6976 D-ERYTHRO-SPHINGOSINE GO 6983 Nintedanib Dasatinib
ABT 263 Ponatinib Ibrutinib GF109203X GANGLIOSIDE GD1A DISODIUM SALT
BISINDOLYLMALEIMIDE VII 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione RO-31-8220 1-METHYLINDOLE-3-ACETAMIDE
RO-31-8220,RO 31-8220 METHANESULFONATE,RO 31-8220 MESYLATE 3-Isopropenyl-1-methyl-1H-pyrrole RO 31-8220 (BISINDOYLMALEIMIDINE IX)
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RO-31-8220 BISINDOLYLMALEIMIDE IX, METHANESULFONATE 3-[1-[3-(AMIDINOTHIO)PROPYL-1H-INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL)MALEIMIDE BISINDOLYLMALEIMIDE IX METHANESULPHONATE SALT BisindolylMaleiMide IX Mesylate BisindolylMaleiMide IX . Methansulfonate [Ro 31-8220] Carbamimidothioic acid, 3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl ester, methanesulfonate (1:1) Ro31-8220MsOH Ro 31-8220 Mesylat Ro 31-8220/Ro318220 Ro-31-8220 - CAS 138489-18-6 - Calbiochem 3-[3-[2,5-Dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl carbamimidothioic acid ester mesylate RO 31-8220 METHANESULFONATE; BISINDOLYLMALEIMIDE IX MESYLATE;RO318220 CS-1132 Bisindolylmaleimide IX (Ro 31-8220 Mesylate) RO-31-8220 USP/EP/BP 3-(3-(4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-1H-indol-1-yl)propyl carbamimidothioate 138489-18-6 C25H23N5O2SCH4O3S C25H23N5O2S C26H27N5O5S2 Smad TGF-beta Inhibitors TGF-beta/Smad inhibitor