Sotalol hydrochloride
- CAS No.
- 959-24-0
- Chemical Name:
- Sotalol hydrochloride
- Synonyms
- DAROB;SOTALEX;SOTACOR;MJ-1999;BETAPACE;DL-MJ 1999;SOTALOL HCL;SOLATOL HCL;Betapace AF;meadjohnson1999
- CBNumber:
- CB9712098
- Molecular Formula:
- C12H21ClN2O3S
- Molecular Weight:
- 308.82
- MOL File:
- 959-24-0.mol
- Modify Date:
- 2024/4/15 15:30:59
| Melting point | 218-220°C |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: 20 mg/mL |
| form | powder |
| color | white to off-white |
| Water Solubility | Soluble in phosphate buffered saline, DMSO, ethanol, water, and methanol. |
| CAS DataBase Reference | 959-24-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H303-H315-H319-H335 |
| Precautionary statements | P261-P280a-P304+P340-P405-P501a-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | PB0826000 |
| HS Code | 2935904000 |
| Toxicity | LD50 in male mice, rats (mg/kg): 2600, 3450 orally; 670, 680 i.p.; LD50 orally in rabbits: 1000 mg/kg; LD50 i.p. in dogs: 330 mg/kg (Lish) |
Sotalol hydrochloride price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S0278 | (±)-Sotalol hydrochloride ≥98% (TLC), powder | 959-24-0 | 25MG | ₹10521.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S0278 | (±)-Sotalol hydrochloride ≥98% (TLC), powder | 959-24-0 | 100MG | ₹33860.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2798 | Sotalol Hydrochloride | 959-24-0 | 500MG | ₹25817.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 39863 | (±)-Sotalol hydrochloride analytical standard | 959-24-0 | 10MG | ₹11777.6 | 2022-06-14 | Buy |
Sotalol hydrochloride Chemical Properties,Uses,Production
Description
Sotalol is a non-selective antagonist of β-adrenergic receptors (β-ARs; IC50s = 8.9 and 5.2 μM for β1- and β2-ARs, respectively) and a class III antiarrhythmic agent. It decreases delayed outward potassium currents (IK) in guinea pig ventricular cells and prolongs action potential duration in electrically stimulated isolated guinea pig papillary muscles when used at a concentration of 100 μM. Sotalol decreases heart rate and increases blood pressure and the cardiac functional refractory period (FRP) in a canine model of ventricular tachycardia induced by programmed electrical stimulation (PES). Formulations containing sotalol have been used in the treatment of ventricular arrhythmias and maintenance of normal sinus rhythm in patients with atrial fibrillation or flutter (AFIB/AFL).
Chemical Properties
White Crystalline Solid
Uses
Sotalol hydrochloride is used as a potent beta adrenergic antagonist, prolongs the action potential and increases the refractory period. Sotalol hydrochloride is also considered a non-selective β blocker and a potassium channel blocker with an IC50 of 43 μM.
Definition
ChEBI: A hydrochloride salt that is the monohydrochloride of sotalol. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
Biological Activity
A relatively potent pure β adrenergic antagonist, unique in possessing additional class III antiarrhythmic activity. Also available as part of the Mixed Adrenergic Tocriset™ .
Sotalol hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Neuland Laboratories Limited | +91 (40) 2341-2934 | New Delhi, India | 24 | 50 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| NEULAND LABORATORIES LTD | +91 40 67611600 / 1700 | New Delhi, India | 55 | 58 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20296 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21669 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
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