5-(4-aMino-1-isopropyl-1H-pyrazolo[3,4-d]pyriMidin-3-yl)benzo[d]oxazol-2-aMine
![5-(4-aMino-1-isopropyl-1H-pyrazolo[3,4-d]pyriMidin-3-yl)benzo[d]oxazol-2-aMine Structure](/CAS/GIF/1224844-38-5.gif)
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- Product name: 5-(4-aMino-1-isopropyl-1H-pyrazolo[3,4-d]pyriMidin-3-yl)benzo[d]oxazol-2-aMine
- CAS: 1224844-38-5
- MF: C15H15N7O
- MW: 309.33
- EINECS:
- MDL Number:MFCD22124893
- Synonyms:5-(4-aMino-1-isopropyl-1H-pyrazolo[3,4-d]pyriMidin-3-yl)benzo[d]oxazol-2-aMine;3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;INK-128;3-(2-aminobenzo[d]oxazol-5-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine;INK-128 3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;MLN0128;5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine;-(4-aMino-1-isopropyl-1H-pyrazolo[3,4-d]pyriMidin-3-yl)benzo[d]oxazol-2-aMine
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Properties
Melting point :270-272°C (dec.)
Boiling point :598.8±60.0 °C(Predicted)
Density :1.64
storage temp. :-20°C
solubility :Soluble in DMSO (up to 25 mg/ml)
pka :3.77±0.30(Predicted)
form :solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Boiling point :598.8±60.0 °C(Predicted)
Density :1.64
storage temp. :-20°C
solubility :Soluble in DMSO (up to 25 mg/ml)
pka :3.77±0.30(Predicted)
form :solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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Description
The mammalian target of rapamycin (mTOR) is a kinase which acts as part of two distinct complexes, TORC1 and TORC2. Both complexes (TORC1/2) play central roles in cell growth, gene expression, angiogenesis, and cell survival. INK128 is an inhibitor of TORC1/2, acting as a sub-nanomolar ATP-dependent inhibitor of mTOR kinase. It blocks the phosphorylation of downstream substrates of both TORC1 and TORC2. INK128 interferes with the growth of cell lines which are resistant to rapamycin and pan-PI3K inhibitors. Moreover, daily, oral administration of INK128 inhibits angiogenesis and tumor growth in several xenograft models. The effects of INK128 on gene expression also reduce invasion and metastasis.More related product prices
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Suppliers and manufacturers
career henan chemical co
![5-(4-aMino-1-isopropyl-1H-pyrazolo[3,4-d]pyriMidin-3-yl)benzo[d]oxazol-2-aMine](https://img.chemicalbook.com/ProductImageEN/2018-12/small/fe498182-1055-4d7c-bbd5-8bbb37f80631.png)
A.J Chemicals
Pharmaffiliates Analytics and Synthetics P. Ltd
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd
TargetMol Chemicals Inc.
₹2.00 /1kg
5-(4-aMino-1-isopropyl-1H-pyrazolo[3,4-d]pyriMidin-3-yl)benzo[d]oxazol-2-aMine CAS:1224844-38-5
5-(4-aMino-1-isopropyl-1H-pyrazolo[3,4-d]pyriMidin-3-yl)benzo[d]oxazol-2-aMine CAS:1224844-38-5