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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >GPCR & G Protein >CXCR antagonist >N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Structure
  • ₹3900 - ₹38829.28
  • Product name: N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine
  • CAS: 55778-02-4
  • MF: C18H18N4
  • MW: 290.36
  • EINECS:200-256-5
  • MDL Number:MFCD18086914
  • Synonyms:1,4-Benzenedimethanamine, N1,N4-di-2-pyridinyl-;N1,N4-di-2-pyridinyl-1,4-benzenedimethanamine WZ811;WZ 811 N,N'-Di-2-pyridinyl-1,4-benzenedimethanamine;WZ 811, >=98%;N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine;WZ 811;N,N'-(1,4-PHENYLENEBIS(METHYLENE))DIPYRIDIN-2-AMINE;N,N'-Di-2-pyridinyl-1,4-benzenedimethanamine
4 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • 100MG
  • ManufacturerTCI Chemicals (India)
  • Product numberW0017
  • Product descriptionWZ 811
  • Packaging25MG
  • Price₹3900
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberW0017
  • Product descriptionWZ 811
  • Packaging100MG
  • Price₹8900
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0088
  • Product descriptionWZ811 ≥98% (HPLC)
  • Packaging5MG
  • Price₹9601.78
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0088
  • Product descriptionWZ811 ≥98% (HPLC)
  • Packaging25MG
  • Price₹38829.28
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) W0017 WZ 811 25MG ₹3900 2022-05-26 Buy
TCI Chemicals (India) W0017 WZ 811 100MG ₹8900 2022-05-26 Buy
Sigma-Aldrich(India) SML0088 WZ811 ≥98% (HPLC) 5MG ₹9601.78 2022-06-14 Buy
Sigma-Aldrich(India) SML0088 WZ811 ≥98% (HPLC) 25MG ₹38829.28 2022-06-14 Buy

Properties

Melting point :192-194℃ (methanol )
Boiling point :493.2±35.0 °C(Predicted)
Density :1.229±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :DMSO: ≥7mg/mL
pka :6.55±0.10(Predicted)
form :powder
color :white to tan

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The CXC chemokine receptor-4 (CXCR4) is a G protein-coupled receptor that is specific for stromal cell-derived factor-1 (SDF-1/ CXCL12). Activation of CXCR4 promotes homing of hematopoietic stem cells, chemotaxis and quiescence of lymphocytes, and growth and metastasis of certain cancer cell types. Moreover, CXCR4 on CD4+ T-cells is used by CXCR4-selective HIV forms as a gateway for T-cell infection. WZ811 is a potent inhibitor of binding of an SDF-1 peptide mimic to CXCR4 (EC50 = 0.3 nM). It prevents SDF-1/CXCL12-mediated modulation of cAMP (EC50 = 1.2 nM) in cells and blocks SDF-1-induced Matrigel? invasion by MDA-MB-231 human breast adenocarcinoma cells (EC50 = 5.2 nM). The effectiveness of WZ811 in animals remains to be elucidated.

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