BISINDOLYLMALEIMIDE II
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- Product name: BISINDOLYLMALEIMIDE II
- CAS: 137592-45-1
- MF: C27H26N4O2
- MW: 438.52
- EINECS:
- MDL Number:MFCD00236430
- Synonyms:BISINDOLYLMALEIMIDE II;3-(1H-Indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione;2-[1-[2-(1-METHYLPYRROLIDINO)ETHYL]-1H-INDOL-3-YL]-3-(1H-INDOL-3-YL)MALEIMIDE;3-(1H-indol-3-yl)-4-[1-[2-(1-methylpyrrolidin-2-yl)ethyl]indol-3-yl]pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-
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Properties
Boiling point :709.9±60.0 °C(Predicted)
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :DMSO: soluble
form :solid
pka :8.17±0.60(Predicted)
color :Yellow to orange
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :DMSO: soluble
form :solid
pka :8.17±0.60(Predicted)
color :Yellow to orange
Safety Information
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Description
Bisindolylmaleimide II (BIM II) is a general inhibitor of all protein kinase C (PKC) subtypes with structural similarity to the nonspecific PKC inhibitor staurosporine. At 10 μM, BIM II inhibits 98% of PKCα kinase activity. Additionally, it inhibits PDK1 (IC50 = 14 μM), an important kinase in the insulin signaling pathway, and PKA (IC50 = 2.94 μM). Studies of structure-activity relationships of BIM II in complex with PDK1 and PKA kinase binding domains has led to useful insights into kinase/ligand binding for the rational design of inhibitors as potential therapeutic agents.Related product price
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