BMS813160
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- ₹0
- Product name: BMS813160
- CAS: 1286279-29-5
- MF: C25H40N8O2
- MW: 484.64
- EINECS:-0
- MDL Number:MFCD31540731
- Synonyms:CS-2742;BMS-813160;BMS813160;BMS 813160;N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide;BMS813160;Acetamide, N-[(1R,2S,5R)-5-[(1,1-dimethylethyl)amino]-2-[(3S)-3-[[7-(1,1-dimethylethyl)pyrazolo[1,5-a]-1,3,5-triazin-4-yl]amino]-2-oxo-1-pyrrolidinyl]cyclohexyl]-;Inhibitor,CC chemokine receptor,CCR,dual antagonist,peritonitis,CD11b,BMS-813160,inflammation,CTX,thioglycollate,BMS813160,inhibit,mouse,oral
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
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Properties
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :4°C, protect from light
solubility :DMSO:61.0(Max Conc. mg/mL);125.86(Max Conc. mM)
Ethanol:97.0(Max Conc. mg/mL);200.14(Max Conc. mM) form :A crystalline solid
pka :15.46±0.60(Predicted)
color :White to off-white
storage temp. :4°C, protect from light
solubility :DMSO:61.0(Max Conc. mg/mL);125.86(Max Conc. mM)
Ethanol:97.0(Max Conc. mg/mL);200.14(Max Conc. mM) form :A crystalline solid
pka :15.46±0.60(Predicted)
color :White to off-white
Safety Information
Symbol(GHS): |
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Signal word: | Danger | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Description
BMS 813160 is a dual antagonist of chemokine receptor 2 (CCR2) and CCR5 (IC50s = 6.2 and 3.6 nM, respectively, in radioligand binding assays). It inhibits chemotaxis induced by the CCR2 ligand MCP-1 in THP-1 cells the CCR5 ligand MIP-1β in isolated peripheral T cells with IC50 values of 0.8 and 1.1 nM, respectively. BMS 813160 inhibits peritoneal monocyte and macrophage infiltration in an hCCR-2 KI mouse model of thioglycolate-induced peritonitis, with 54% inhibition when administered at a dose of 50 mg/kg twice per day.More related product prices
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Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
InvivoChem
TargetMol Chemicals Inc.
Wuhan Topule Biopharmaceutical Co., Ltd
Aladdin Scientific
Wuhan Jingkang en Biomedical Technology Co., Ltd
InvivoChem
Shanghai Lollane Biological Technology Co.,Ltd.
Changzhou Chenhong Biotechnology Co., Ltd.
Shanghai Aladdin Biochemical Technology Co.,Ltd.