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ChemicalBook > Product Catalogue >API >Circulatory system drugs >Antihypertensive drugs >DIAZOXIDE

DIAZOXIDE

DIAZOXIDE Structure
  • ₹2700 - ₹98962.15
  • Product name: DIAZOXIDE
  • CAS: 364-98-7
  • MF: C8H7ClN2O2S
  • MW: 230.67
  • EINECS:206-668-1
  • MDL Number:MFCD00078578
  • Synonyms:Eudemine ;DIAZOXIDE ACTIVATOR OF ATP-DEPE;DIAZOXIDE,USP;NSC-64198;Sch-6783;7-chloro-3-methyl-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide;Diazoxide,7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide;2h-1,2,4-benzothiadiazine,7-chloro-3-methyl-,1,1-dioxide
5 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 250MG
  • 1G
  • 5G
  • ManufacturerTCI Chemicals (India)
  • Product numberD5402
  • Product descriptionDiazoxide
  • Packaging250MG
  • Price₹2700
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberD5402
  • Product descriptionDiazoxide
  • Packaging1G
  • Price₹10500
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberD9035
  • Product descriptionDiazoxide
  • Packaging250MG
  • Price₹9612.6
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberD9035
  • Product descriptionDiazoxide
  • Packaging1G
  • Price₹30948.68
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberD9035
  • Product descriptionDiazoxide
  • Packaging5G
  • Price₹98962.15
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) D5402 Diazoxide 250MG ₹2700 2022-05-26 Buy
TCI Chemicals (India) D5402 Diazoxide 1G ₹10500 2022-05-26 Buy
Sigma-Aldrich(India) D9035 Diazoxide 250MG ₹9612.6 2022-06-14 Buy
Sigma-Aldrich(India) D9035 Diazoxide 1G ₹30948.68 2022-06-14 Buy
Sigma-Aldrich(India) D9035 Diazoxide 5G ₹98962.15 2022-06-14 Buy

Properties

Melting point :>310°C
Boiling point :414.8±47.0 °C(Predicted)
Density :1.3767 (rough estimate)
refractive index :1.6300 (estimate)
storage temp. :2-8°C
solubility :0.1 M NaOH: soluble
form :Solid
pka :pKa 8.5 (Uncertain)
color :White
Water Solubility :Soluble in 0.1M NaOH. Insoluble in water or in methanol.
λmax :268nm(MeOH)(lit.)
Merck :14,3004
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Diazoxide is a potassium channel activator that causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. The cellular release of potassium switches off voltage-gated calcium ion channels which inhibits the generation of an action potential. Diazoxide relaxes rat aorta rings with an ED50 value of 19.3 μM and has been used as a vasodilator in the treatment of hypertension. Diazoxide also decreases the secretion of insulin by activating pancreatic β cell potassium channels and, thus, it has been used to counter hypoglycemia in certain disease states.

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