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H-8 DIHYDROCHLORIDE

H-8 DIHYDROCHLORIDE Structure
  • ₹15469.99 - ₹15544.7
  • Product name: H-8 DIHYDROCHLORIDE
  • CAS: 113276-94-1
  • MF: C12H17Cl2N3O2S
  • MW: 338.25
  • EINECS:
  • MDL Number:MFCD00036962
  • Synonyms:5-IsoquinolinesulfonaMide,N-[2-(MethylaMino)ethyl]-, hydrochloride (1:2);H-8 DIHYDROCHLORIDE;H-8 HYDROCHLORIDE;H-8;N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE 2HCL;N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE, DI-HCL SALT;N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE DIHYDROCHLORIDE;N-(2-[METHYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE
Price2 Properties Safety Information Description
2 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product number371958
  • Product descriptionH-8, Dihydrochloride A potent, cell-permeable, reversible, and ATP-competitive inhibitor of cyclic-nucleotide-dependent protein kinases.
  • Packaging1MG
  • Price₹15469.99
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberM9656
  • Product descriptionH-8 dihydrochloride >98% (HPLC)
  • Packaging5MG
  • Price₹15544.7
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 371958 H-8, Dihydrochloride A potent, cell-permeable, reversible, and ATP-competitive inhibitor of cyclic-nucleotide-dependent protein kinases. 1MG ₹15469.99 2022-06-14 Buy
Sigma-Aldrich(India) M9656 H-8 dihydrochloride >98% (HPLC) 5MG ₹15544.7 2022-06-14 Buy

Properties

Melting point :221-222℃ (methanol water )
storage temp. :2-8°C
solubility :ethanol: 25 mg/mL, clear, colorless
form :Lyophilized
color :White to Off-White
CAS DataBase Reference :113276-94-1(CAS DataBase Reference)

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

The H series isoquinolinesulfonamide protein kinase (PK) inhibitors are widely used to block signaling pathways to elucidate mechanisms of cellular regulation and signal transduction. H-8, an isoquinolinesulfonamide protein kinase (PK) inhibitor, is a potent inhibitor of PKA and PKG and shows moderate inhibition for PKC and MLCK with Ki values of 1.2, 0.48, 15, and 68 μM, respectively. H-8 can disrupt transcriptional elongation by inhibiting cyclin C/Cdk8 and cyclin H/Cdk7/p36 CTD kinase activity with IC50 values of 47 and 6.2 μM, respectively.

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