Mirin
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- ₹9006.4 - ₹35744.15
- Product name: Mirin
- CAS: 299953-00-7
- MF: C10H8N2O2S
- MW: 220.25
- EINECS:683-709-3
- MDL Number:MFCD05885480
- Synonyms:5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one;MRN-ATM Pathway Inhibitor, Mirin;(5E)-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one;(E)-5-(4-hydroxybenzylidene)-2-iminothiazolidin-4-one;4(5H)-Thiazolone, 2-amino-5-[(4-hydroxyphenyl)methylene]-;Mirin >=98% (HPLC), powder
3 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 10MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberM9948
- Product descriptionMirin ≥98% (HPLC), powder
- Packaging5MG
- Price₹9006.4
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number475954
- Product descriptionMRN-ATM Pathway Inhibitor, Mirin - CAS 299953-00-7 - Calbiochem The MRN-ATM Pathway Inhibitor, Mirin, also referenced under CAS 299953-00-7, controls the biological activity of Mre11, component of the MRN (Mre11-Ra
- Packaging10MG
- Price₹9490
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberM9948
- Product descriptionMirin ≥98% (HPLC), powder
- Packaging25MG
- Price₹35744.15
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | M9948 | Mirin ≥98% (HPLC), powder | 5MG | ₹9006.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 475954 | MRN-ATM Pathway Inhibitor, Mirin - CAS 299953-00-7 - Calbiochem The MRN-ATM Pathway Inhibitor, Mirin, also referenced under CAS 299953-00-7, controls the biological activity of Mre11, component of the MRN (Mre11-Ra | 10MG | ₹9490 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M9948 | Mirin ≥98% (HPLC), powder | 25MG | ₹35744.15 | 2022-06-14 | Buy |
Properties
Melting point :295-297 °C(Solv: ethanol (64-17-5))
Boiling point :441.6±55.0 °C(Predicted)
Density :1.49±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
form :Reddish orange powder
pka :9.15±0.30(Predicted)
color :red to orange
Sensitive :Moisture Sensitive
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Boiling point :441.6±55.0 °C(Predicted)
Density :1.49±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
form :Reddish orange powder
pka :9.15±0.30(Predicted)
color :red to orange
Sensitive :Moisture Sensitive
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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Description
The Mre11-Rad50-Nbs1 (MRN) complex acts as a DNA damage sensor, maintains genome stability during DNA replication, and activates and recruits ataxia-telangiectasia mutated (ATM) to damaged DNA. The genes that encode the MRN proteins are all essential for cell viability, so functional studies of MRN cannot involve deletion of these genes. Mirin is an inhibitor of MRN, inhibiting MRN-dependent phosphorylation of histone H2AX (IC50 = 66 μM). Through its effects on MRN, mirin prevents activation of ATM. Inhibition of MRN centers on the ability of mirin to block the nuclease activity of Mre11, rather than altering DNA-binding or MRN complex formation. In cells, mirin induces G2 arrest, abolishes the radiation-induced G2/M checkpoint, and prevents homology-directed repair of DNA damage.More related product prices
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