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OLOMOUCINE

OLOMOUCINE Structure
  • ₹5880 - ₹32702.33
  • Product name: OLOMOUCINE
  • CAS: 101622-51-9
  • MF: C15H18N6O
  • MW: 298.34
  • EINECS:
  • MDL Number:MFCD00189360
  • Synonyms:6-BENYLAMINO-2-(2-HYDROXYETHYLAMINO)-9-METHYLPURINE;6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-9-METHYLPURINE;2-(2'-Hydroxyethylamino)-9-methyl-6-(benzylamino)purine;2-(hydroxyethylamino)-6-benzylamino-9-methylpurine;2-[[9-METHYL-6[(PHENYLMETHYL)AMINO]-9H-PURIN-2-YL]AMINO]-ETHANOL;2-(2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-METHYLPURINE;N2-[(2-HYDROXYETHYL)]-N6-BENZYLADENINE;OLOMOUCINE
4 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product number495620
  • Product descriptionOlomoucine - CAS 101622-51-9 - Calbiochem A purine derivative that acts as a potent, reversible and selective inhibitor of p34cdk1/cyclin B and related kinases.
  • Packaging1MG
  • Price₹5880
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberO0886
  • Product descriptionOlomoucine ≥98% (HPLC)
  • Packaging1MG
  • Price₹8887.33
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number495620
  • Product descriptionOlomoucine - CAS 101622-51-9 - Calbiochem A purine derivative that acts as a potent, reversible and selective inhibitor of p34cdk1/cyclin B and related kinases.
  • Packaging5MG
  • Price₹22650
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberO0886
  • Product descriptionOlomoucine ≥98% (HPLC)
  • Packaging5MG
  • Price₹32702.33
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 495620 Olomoucine - CAS 101622-51-9 - Calbiochem A purine derivative that acts as a potent, reversible and selective inhibitor of p34cdk1/cyclin B and related kinases. 1MG ₹5880 2022-06-14 Buy
Sigma-Aldrich(India) O0886 Olomoucine ≥98% (HPLC) 1MG ₹8887.33 2022-06-14 Buy
Sigma-Aldrich(India) 495620 Olomoucine - CAS 101622-51-9 - Calbiochem A purine derivative that acts as a potent, reversible and selective inhibitor of p34cdk1/cyclin B and related kinases. 5MG ₹22650 2022-06-14 Buy
Sigma-Aldrich(India) O0886 Olomoucine ≥98% (HPLC) 5MG ₹32702.33 2022-06-14 Buy

Properties

Melting point :120-130 °C
Boiling point :579.6±60.0 °C(Predicted)
Density :1.36
storage temp. :-20°C
solubility :DMSO, Methanol (Slightly)
pka :14.55±0.10(Predicted)
form :Solid
color :White to off-white
CAS DataBase Reference :101622-51-9(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Olomoucine is a purine that acts as a competitive inhibitor of a variety of cell cycle regulating proteins with high specificity, which leads to the blockage of some cell cycle steps. The compound inhibits: Cdc2/cyclin B, Cdk2/cyclin A and Cdk2/cyclin E kinases, the brain Cdk5/p35 kinase and the ERK1/MAP-kinase. Olomoucine does not significantly inhibit Cdk4/cyclin D1 and Cdk6/cyclin D3 kinases. The compound can induce cell arrest at G1/S and the G2/M, due to its effect on Ckd2 and Cdcd2. Olomoucine also behaves as a competitive inhibitor for ATP and as a non-competitive inhibitor for histone H1 in terms of being Cdk substrates.

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