SU 9516
- ₹0
- Product name: SU 9516
- CAS: 377090-84-1
- MF: C13H11N3O2
- MW: 241.25
- EINECS:
- MDL Number:MFCD05865243
- Synonyms:(Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one;(Z)-3-((1H-iMidazol-4-yl)Methylene)-5-Methoxyindolin-2-one;(Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one SU9516;(3Z)-1,3-Dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-2H-indol-2-one;3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one;CS-1784;3-(1H-imidazol-5-ylmethylidene)-5-methoxy-1H-indol-2-one;SU 9516;SU-9516
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Properties
storage temp. :Store at +4°C
solubility :DMSO: ~17 mg/mL
form :crystalline
color :brown
solubility :DMSO: ~17 mg/mL
form :crystalline
color :brown
Safety Information
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Description
SU 9516 is a 3-substituted indolinone that has anti-proliferative and pro-apoptotic activity in tumor cells. It is a potent inhibitor of several cyclin-dependent kinases (CDKs) with selectivity for Cdk2 (IC50s = 22, 40, and 200 nM for Cdk2/cyclin A, Cdk1/cyclin B, and Cdk4/cyclin D1). It does not inhibit PKC, p38, PDGFR, or EGFR (IC50’s = >10 μM). SU 9516 inhibits phosphorylation of the retinoblastoma protein pRb, resulting in increased pRb/E2F complex formation, cell-cycle arrest, and subsequent apoptosis. In leukemia cells (U937, Jurkat, and HL-60 cells) SU 9516 downregulates transcription of the antiapoptotic protein Mcl-1, leading to mitochondrial injury and cell death.Related product price
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