PIK-75 Hydrochloride
|
- ₹0
- Product name: PIK-75 Hydrochloride
- CAS: 372196-77-5
- MF: C16H15BrClN5O4S
- MW: 488.7434
- EINECS:
- MDL Number:MFCD12546130
- Synonyms:2-Methyl-5-nitrobenzenesulfonic acid [(6-bromoimidazo[1,2-a]pyridin-3-yl)methylene]methylhydrazide hydrochloride;PFK-15;(E)-N'-((6-bromoH-imidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide hydrochloride;2-Methyl-5-nitrobenzenesulfonic acid [(6-bromoimidazo[1,2-a]pyridin-3-yl)methylene]methylhydrazide hydrochloride PIK-75;Benzenesulfonic acid, 2-methyl-5-nitro-, 2-[(6-bromoimidazo[1,2-a]pyridin-3-yl)methylene]-1-methylhydrazide, hydrochloride (1:1);PIK-75;PIK 75;(E)-N'-((6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydraz;PIK-75 HCl
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|
Properties
Melting point :>156°C (dec.)
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
color :Light Beige to Beige
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
color :Light Beige to Beige
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||
| Precautionary statements: |
|
Description
PIK-75 blocks production of PIP2 and/or PIP3, phosphorylation of Akt, and activation of mTORC1 in adipocytes and myotubes. PI 3-kinase (PI3K) catalyzes the synthesis of the second messengers PtdIns-(3)-P, PtdIns-(3,4)-P2, and PtdIns-(3,4,5)-P3. The PI 3-kinase family of enzymes is comprised of 15 members that are divided into three classes according to their structure, substrate specificity, and mode of regulation. In the class I PI 3-kinases, p110α is the primary PI 3-kinase isoform required for insulin signaling in adipocytes and myotubes and is frequently mutated in primary tumors. Small molecule inhibitors of p110α are of interest in cancer treatment research. PIK-75 is an imidazopyridine that selectively inhibits p110α with an IC50 value of 5.8 nM. PIK-75 inhibits p110γ and p110β considerably less effectively.More related product prices
BEZ235 (NVP-BEZ235, Dactolisib) 4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- FLAVOPIRIDOL HYDROCHLORIDE CAL-101 Pictilisib (GDC-0941) 1217486-61-7 Metanilic acid Benzoic acid Sulfanilic acid N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide PIK-294 593960-11-3Related product price
- FLAVOPIRIDOL HYDROCHLORIDE
₹14873.55-59396.78 - Metanilic acid
₹200-6386.75 - Benzoic acid
₹430-268384.23
