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ChemicalBook > Product Catalogue >Analytical Chemistry >Standard >Pharmaceutical Impurity Reference Standards >Paricalcitol

Paricalcitol

Paricalcitol Structure
  • ₹0
  • Product name: Paricalcitol
  • CAS: 131918-61-1
  • MF: C27H44O3
  • MW: 416.65
  • EINECS:658-064-6
  • MDL Number:
  • Synonyms:1α,25-Dihydroxy-19-nor-vitaMin D2;Paricalcitol/ 19-nor-1α,25-dihydroxyergocalciferol;PARICALCITOL (10 MG)F0E3030.997MG/MG(AI);PARICALCITOL;19-nor-1alpha,25-dihydroxyvitamin D2;(1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-Hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol;1,3-Cyclohexanediol, 5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3R,5Z)-;Paricalcitol, >=98%
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :564.8±50.0 °C(Predicted)
Density :1.121±0.06 g/cm3(Predicted)
Flash point :14℃
storage temp. :Store at -20°C,unstable in solution, ready to use.
solubility :DMSO : 100 mg/mL (240.02 mM; Need ultrasonic)Ethanol : 12.5 mg/mL (30.00 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
pka :14.34±0.40(Predicted)
form :Solid
color :White to off-white
InChIKey :BPKAHTKRCLCHEA-UBFJEZKGSA-N
SMILES :C[C@]12CCC/C(=C\C=C3C[C@@H](O)C[C@H](O)C3)/[C@]1([H])CC[C@]2([H])[C@H](C)/C=C/[C@H](C)C(O)(C)C |&1:1,10,13,16,20,22,26,r|
CAS DataBase Reference :131918-61-1(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H330 Fatal if inhaled Acute toxicity,inhalation Category 1, 2 Danger GHS hazard pictograms P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P314 Get medical advice/attention if you feel unwell.

Description

1,25-Dihydroxy vitamin D2 is a potent agonist of the vitamin D receptor. Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.

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Suppliers and manufacturers

Dishman Carbogen Amcis Ltd (Dishman Group) Hetero Drugs Limited EAGLE CHEMICAL WORKS Sai Life Sciences Ltd Pharmaffiliates Analytics and Synthetics P. Ltd SynZeal Research Pvt Ltd Sai Life Sciences Ltd. Mahalaxmi Chemi Pharma CLEARSYNTH LABS LTD. NEULAND LABORATORIES LTD