SD-208
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- ₹17731.35
- Product name: SD-208
- CAS: 627536-09-8
- MF: C17H10ClFN6
- MW: 352.75
- EINECS:
- MDL Number:MFCD09038685
- Synonyms:SD-208;2-[(5-CHLORO-2-FLUOROPHENYL)PTERIDIN-4-YL]PYRIDIN-4-YL-AMINE;2-(5-Chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]pteridine;2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine;4-PteridinaMine, 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-;2-(5-Chloro-2-fluorophenyl)-N-4-pyridinyl-4-pteridinamine;SCI 208;2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-
1 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product numberS7071
- Product descriptionSD-208 ≥98% (HPLC), powder
- Packaging5MG
- Price₹17731.35
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S7071 | SD-208 ≥98% (HPLC), powder | 5MG | ₹17731.35 | 2022-06-14 | Buy |
Properties
Boiling point :460.4±45.0 °C(Predicted)
Density :1.487
storage temp. :2-8°C
solubility :DMSO: >5mg/mL
pka :4.56±0.26(Predicted)
form :powder
color :off-white to tan
Density :1.487
storage temp. :2-8°C
solubility :DMSO: >5mg/mL
pka :4.56±0.26(Predicted)
form :powder
color :off-white to tan
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
TGF-β is a cell growth and differentiation factor that has roles in cancer, fibrosis, and numerous other pathologies. TGF-β signals through two receptor tyrosine kinases, TGF-βRI and TGF-βRII. SD 208 is a potent inhibitor of TGF-βRI kinase (EC50 = 48 nM) that has minimal or no effect at a variety of other tyrosine or serine/threonine kinases, including TGF-βRII kinase. It blocks both autocrine and paracrine TGF-β signaling in glioma cells, inhibiting TGF-β-induced migration and invasion without affecting viability or proliferation. SD 208 is orally bioavailable and prevents TGF-β-induced Smad phosphorylation in spleens and brains of mice. It improves survival in mice with xenografted glioma by heightening the immune response against tumor cells and reverses bronchial hyperresponsiveness to allergens in ovalbumin-exposed mice. SD 208 also suppresses TGF-β-induced differentiation of proliferating myofibroblasts and induces dedifferentiation in the absence of TGF-β.More related product prices
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