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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Cell Cycle >CDK inhibitors >TG003

TG003

TG003 Structure
  • ₹17190.1 - ₹75179.63
  • Product name: TG003
  • CAS: 300801-52-9
  • MF: C13H15NO2S
  • MW: 249.33
  • EINECS:
  • MDL Number:MFCD00624584
  • Synonyms:Cdc2-Like Kinase Inhibitor, TG003;TG003/TG-003;2-Propanone,1-(3-ethyl-5-Methoxy-2(3H)-benzothiazolylidene)-;(1Z)-1-(3-Ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one;1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone;(Z)-1-(3-ethyl-5-methoxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one;CS-955;CS-1704
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberT5575
  • Product descriptionTG003 ≥98% (HPLC)
  • Packaging5MG
  • Price₹17190.1
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT5575
  • Product descriptionTG003 ≥98% (HPLC)
  • Packaging25MG
  • Price₹75179.63
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) T5575 TG003 ≥98% (HPLC) 5MG ₹17190.1 2022-06-14 Buy
Sigma-Aldrich(India) T5575 TG003 ≥98% (HPLC) 25MG ₹75179.63 2022-06-14 Buy

Properties

Melting point :132-132.5 °C
Boiling point :386.0±42.0 °C(Predicted)
Density :1.237±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 33 mg/mL
form :solid
pka :-1.76±0.20(Predicted)
color :pale yellow
Sensitive :Light Sensitive

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

Cdc2-like kinase (Clk), among a number of other kinases, phosphorylates serine/arginine-rich proteins which play a role in alternative splicing of pre-mRNA. The Clk family consists of four members, which include Clk1/Sty and Clk2-4. TG003 is a novel benzothiazole compound that demonstrates potent inhibition of Clk1/Sty and Clk4 with IC50 values of 20 and 15 nM, respectively. TG003 exhibits considerably weaker inhibition of Clk2 and Clk3 (IC50 = 200 nM and >10 μM, respectively). Through suppression of Clk-mediated phosphorylation, TG003 inhibits SF2/ASF-dependent splicing of β-globin pre-mRNA at 1 μM in vitro. At 10 μM, TG003 rescues the embryonic defects induced by excessive Clk activity in Xenopus.

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