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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >DNA damage >Topoisomerase inhibitors >BETA-LAPACHONE

BETA-LAPACHONE

BETA-LAPACHONE Structure
  • ₹17146.8
  • Product name: BETA-LAPACHONE
  • CAS: 4707-32-8
  • MF: C15H14O3
  • MW: 242.27
  • EINECS:
  • MDL Number:MFCD01712233
  • Synonyms:BETA-LAPACHONE;2-b)pyran-5,6-dione,3,4-dihydro-2,2-dimethyl-2h-naphtho( ;B-LAPACHONE,2,2-DIMETHYL-3,4-DIHYDRO-2H-BENZO[H]CHROMENE-5,6-DIONE;3,4-DIHYDRO-2,2-DIMETHYL-2H-NAPHTHO[1,2-B]PYRAN-5,6-DIONE;3,4-DIHYDRO-2,2-DIMETHYL-2H-NAPHTHOL[1,2-B]PYRAN-5,6-DIONE;2,2-Dimethyl-3,4,5,6-tetrahydro-2H-naphtho[1,2-b]pyran-5,6-dione;2,2-dimethyl-3,4-dihydrobenzo[h]chromene-5,6-dione;β-Lapachone (90%)
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Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberL2037
  • Product descriptionβ-Lapachone ≥98% (TLC)
  • Packaging5MG
  • Price₹17146.8
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) L2037 β-Lapachone ≥98% (TLC) 5MG ₹17146.8 2022-06-14 Buy

Properties

Melting point :>110°C (dec.)
Boiling point :381.4±42.0 °C(Predicted)
Density :1.25±0.1 g/cm3(Predicted)
storage temp. :Inert atmosphere,Room Temperature
solubility :Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml)
form :Orange to brown solid.
color :Orange
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code
InChIKey :QZPQTZZNNJUOLS-UHFFFAOYSA-N
LogP :2.820 (est)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

β-Lapachone is a natural quinone with diverse anti-cancer and anti-inflammatory effects. It inhibits topoisomerase I at 25 μM and transglutaminase (IC50 = 5 μM). In cancer cells which overexpress NAD(P)H:quinone oxidoreductase, β-lapachone is reduced to β-lapachone hydroquinone, which generates reactive oxygen species during its reversion to β-lapachone. This process sensitizes cancer cells to radiation, suppresses NF-κB activation, and drives apoptosis.

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