CX-5461
- ₹23559.99
- Product name: CX-5461
- CAS: 1138549-36-6
- MF: C27H27N7O2S
- MW: 513.61
- EINECS:
- MDL Number:MFCD21609261
- Synonyms:CX-5461;2-(4-Methyl-1,4-diazepan-1-yl)-N-((5-Methylpyrazin-2-yl)Methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxaMide;RNA Polymerase I Inhibitor II, CX-5461 - CAS 1138549-36-6 - Calbiochem;CS-1938;2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-N-[(5-methyl-2-pyrazinyl)methyl]-5-oxo-5H-benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxamide;CX-5461/CX5461;2-(Hexahydro-4-Methyl-1H-1,4-diazepin-1-yl)-N-[(5-Methyl-2-pyrazinyl)Methyl]-5-oxo-5H-benzothiazolo[3,2-a][1,8]napht;5H-Benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxamide, 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-N-[(5-methyl-2-pyrazinyl)methyl]-5-oxo-
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Brand
- Sigma-Aldrich(India)
Package
- 10MG
- ManufacturerSigma-Aldrich(India)
- Product number5.09265
- Product descriptionRNA Polymerase I Inhibitor II, CX-5461 - CAS 1138549-36-6 - Calbiochem A cell-permeable, selective inhibitor of RNA polymerase I-mediated pre-rRNA transcription (IC?? = 142 nM in HCT-116 cells).
- Packaging10MG
- Price₹23559.99
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 5.09265 | RNA Polymerase I Inhibitor II, CX-5461 - CAS 1138549-36-6 - Calbiochem A cell-permeable, selective inhibitor of RNA polymerase I-mediated pre-rRNA transcription (IC?? = 142 nM in HCT-116 cells). | 10MG | ₹23559.99 | 2022-06-14 | Buy |
Properties
Boiling point :739.9±60.0 °C(Predicted)
Density :1.45
storage temp. :+2C to +8C
solubility :insoluble in H2O; insoluble in EtOH; insoluble in DMSO
form :Light beige powder
pka :8.53±0.20(Predicted)
color :White to yellow
Density :1.45
storage temp. :+2C to +8C
solubility :insoluble in H2O; insoluble in EtOH; insoluble in DMSO
form :Light beige powder
pka :8.53±0.20(Predicted)
color :White to yellow
Safety Information
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Description
CX-5461 is an inhibitor of ribosomal RNA (rRNA) synthesis. It selectively inhibits RNA polymerase I-driven transcription of rRNA in HCT-116, A375, and MIA PaCa-2 tumor cells (IC50s = 142, 113, and 54 nM, respectively) without affecting RNA polymerase II (IC50 > 25μM), DNA replication, or protein translation. At 50 mg/kg, CX-5461 demonstrates in vivo antitumor activity against human solid tumors in mouse xenograft models.More related product prices
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