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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Metabolism >Ferroptosis inhibitors >Ferrostatin-1 (Fer-1)

Ferrostatin-1 (Fer-1)

Ferrostatin-1 (Fer-1) Structure
  • ₹7653.28 - ₹31262.6
  • Product name: Ferrostatin-1 (Fer-1)
  • CAS: 347174-05-4
  • MF: C15H22N2O2
  • MW: 262.35
  • EINECS:
  • MDL Number:MFCD08072959
  • Synonyms:Ethyl 3-amino-4-(cyclohexylamino)benzoate;Benzoic acid, 3-amino-4-(cyclohexylamino)-, ethyl ester;3-Amino-4-cyclohexylaminobenzoic acid ethyl ester;Ferrostatin-1 (Fer-1);Fer 1;Fer1;Fer-1;FER-1;FER 1;FER1;FERROSTATIN-1;FERROSTATIN 1;FERROSTATIN1
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0583
  • Product descriptionFerrostatin-1 ≥95% (HPLC)
  • Packaging5MG
  • Price₹7653.28
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0583
  • Product descriptionFerrostatin-1 ≥95% (HPLC)
  • Packaging25MG
  • Price₹31262.6
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML0583 Ferrostatin-1 ≥95% (HPLC) 5MG ₹7653.28 2022-06-14 Buy
Sigma-Aldrich(India) SML0583 Ferrostatin-1 ≥95% (HPLC) 25MG ₹31262.6 2022-06-14 Buy

Properties

Boiling point :437.3±35.0 °C(Predicted)
Density :1.150±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL, clear
pka :4.78±0.11(Predicted)
form :powder
color :purple to brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChIKey :UJHBVMHOBZBWMX-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Ferrostatin-1 inhibits a specific type of non-apoptotic, iron-dependent, oxidative cell death termed ferroptosis (IC50 = 60 nM), which is induced by the oncogenic Ras-selective compound, erastin . Ferrostatin-1 prevents ferroptosis in cancer cells as well as glutamate-induced cell death in organotypic rat brain slices. Ferrostatin-1 also inhibits cell death in models of Huntington’s disease, periventricular leukomalacia, and kidney dysfunction where it has been found to prevent the accumulation of cytosolic and lipid reactive oxygen species.

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