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ChemicalBook > Product Catalogue >API >Synthetic Anti-infective Drugs >Antifungal Drugs >5-Fluorocytosine

5-Fluorocytosine

5-Fluorocytosine Structure
  • ₹603 - ₹119854.4
  • Product name: 5-Fluorocytosine
  • CAS: 2022-85-7
  • MF: C4H4FN3O
  • MW: 129.09
  • EINECS:217-968-7
  • MDL Number:MFCD00006035
  • Synonyms:4-amino-5-fluoro-2(1h)-pyrimidinon ;4-Amino-5-fluoro-2(1H)-pyrmidinone ;5-fluorocystosine ;5-fluoro-cytosin ;fluocytosine ;4-Amino-5-Fluoro-2(1H)-pyrimidine, Flucytosine, 5-FC;5-Fluorocytosine98%;5-FLUOROCYTOSINE(FLUCYTOSINE)
Price11 Properties Safety Information Description
11 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)
  • SRL
  • ottokemi

Package

  • 250mg
  • 1gm
  • 1G
  • 5gm
  • 5G
  • 25G
  • 25gm
  • 1Gms
  • 5Gms
  • ManufacturerTCI Chemicals (India)
  • Product numberF0321
  • Product description5-Fluorocytosine
  • Packaging1G
  • Price₹2600
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberF0321
  • Product description5-Fluorocytosine
  • Packaging5G
  • Price₹6400
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberF0321
  • Product description5-Fluorocytosine
  • Packaging25G
  • Price₹9700
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberF7129
  • Product description5-Fluorocytosine nucleoside analog
  • Packaging1G
  • Price₹24713.48
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberF7129
  • Product description5-Fluorocytosine nucleoside analog
  • Packaging5G
  • Price₹119854.4
  • Updated2022-06-14
  • Buy
  • ManufacturerSRL
  • Product number24245
  • Product description5-Fluorocytosine (5-FCtys) extrapure, 98%
  • Packaging1Gms
  • Price₹2100
  • Updated2022-05-26
  • Buy
  • ManufacturerSRL
  • Product number24245
  • Product description5-Fluorocytosine (5-FCtys) extrapure, 98%
  • Packaging5Gms
  • Price₹6830
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number F 1464
  • Product description5-Fluoro cytosine 99%
  • Packaging250mg
  • Price₹603
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number F 1464
  • Product description5-Fluoro cytosine 99%
  • Packaging1gm
  • Price₹909
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number F 1464
  • Product description5-Fluoro cytosine 99%
  • Packaging5gm
  • Price₹2619
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number F 1464
  • Product description5-Fluoro cytosine 99%
  • Packaging25gm
  • Price₹11692
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) F0321 5-Fluorocytosine 1G ₹2600 2022-05-26 Buy
TCI Chemicals (India) F0321 5-Fluorocytosine 5G ₹6400 2022-05-26 Buy
TCI Chemicals (India) F0321 5-Fluorocytosine 25G ₹9700 2022-05-26 Buy
Sigma-Aldrich(India) F7129 5-Fluorocytosine nucleoside analog 1G ₹24713.48 2022-06-14 Buy
Sigma-Aldrich(India) F7129 5-Fluorocytosine nucleoside analog 5G ₹119854.4 2022-06-14 Buy
SRL 24245 5-Fluorocytosine (5-FCtys) extrapure, 98% 1Gms ₹2100 2022-05-26 Buy
SRL 24245 5-Fluorocytosine (5-FCtys) extrapure, 98% 5Gms ₹6830 2022-05-26 Buy
ottokemi F 1464 5-Fluoro cytosine 99% 250mg ₹603 2022-05-26 Buy
ottokemi F 1464 5-Fluoro cytosine 99% 1gm ₹909 2022-05-26 Buy
ottokemi F 1464 5-Fluoro cytosine 99% 5gm ₹2619 2022-05-26 Buy
ottokemi F 1464 5-Fluoro cytosine 99% 25gm ₹11692 2022-05-26 Buy

Properties

Melting point :298-300 °C (dec.) (lit.)
Density :1.3990 (estimate)
vapor pressure :0Pa at 25℃
storage temp. :2-8°C
solubility :Sparingly soluble in water, slightly soluble in ethanol (96 per cent)
form :Crystalline Powder
pka :3.26(at 25℃)
color :White to almost white
Water Solubility :1.5g/100mL (25 ºC)
Sensitive :Light Sensitive
Merck :14,4125
BRN :127285
BCS Class :1
Stability :Light Sensitive
InChIKey :XRECTZIEBJDKEO-UHFFFAOYSA-N
LogP :-1.36 at 22.1℃ and pH6.4-6.9
Dissociation constant :2.74-10.71 at 21.4℃
CAS DataBase Reference :2022-85-7(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

5-Fluorocytosine (5-FC), a fluorinated pyrimidine analog, is a synthetic antimycotic prodrug that is converted by cytosine deaminase to 5-fluorouracil. 5-fluorouracil, a widely used cytotoxic drug, is further metabolized to fluorinated ribo- and deoxyribonucleotides, resulting in the inhibition of DNA and protein synthesis, which has multiple effects including inhibition of Candida species and C. neoformans infections and cytotoxicity towards cancer cells. In combination with a retroviral replicating vector carrying a cytosine deaminase prodrug-activating gene, 5-FC has been shown to selectively eliminate CT26 and Tu-2449 tumor cells in vitro (IC50s = 4.2 and 1.5 μM, respectively) and to significantly improve survival and reduce tumor size (at a dose of 500 mg/kg) in two different syngeneic mouse glioma models.

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Suppliers and manufacturers

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