M348
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- ₹10619.33 - ₹42877.83
- Product name: M348
- CAS: 899713-86-1
- MF: C18H17ClF3N3O3
- MW: 415.79
- EINECS:809-791-4
- MDL Number:MFCD05123530
- Synonyms:M348;ML348;N-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide;CS-2370;ML-348 (ML348);GNF-Pf-1127;ML 348;GNF-PF-1127;1-Piperazineacetamide, N-[2-chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML1901
- Product descriptionML348 ≥98% (HPLC)
- Packaging5MG
- Price₹10619.33
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1901
- Product descriptionML348 ≥98% (HPLC)
- Packaging25MG
- Price₹42877.83
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1901 | ML348 ≥98% (HPLC) | 5MG | ₹10619.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1901 | ML348 ≥98% (HPLC) | 25MG | ₹42877.83 | 2022-06-14 | Buy |
Properties
Boiling point :546.2±50.0 °C(Predicted)
Density :1.422±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : 25 mg/mL (60.13 mM; Need ultrasonic)
form :Powder
pka :13.13±0.70(Predicted)
color :White to off-white
Density :1.422±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : 25 mg/mL (60.13 mM; Need ultrasonic)
form :Powder
pka :13.13±0.70(Predicted)
color :White to off-white
Safety Information
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| Signal word: | Danger | ||||||||||||||||
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Description
Lysophospholipase 1 (LYPLA1) is a protein palmitoyl thioesterase responsible for depalmitoylation of the oncogene HRas. Palmitoylation of such oncogenes is thought to be required for trafficking and malignant transformation, making LYPLA1 a target for downregulating oncogenic signaling. ML348 is a reversible LYPLA1 inhibitor with an IC50 value of 210 nM. It is 14-fold selective for LYPLA1 over LYPLA2 (IC50 = >3,000) and demonstrates little activity against a panel of more than 20 other serine hydrolases (IC50s = >10,000).More related product prices
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