PD 0325901
- ₹15891.1 - ₹60457.63
- Product name: PD 0325901
- CAS: 391210-10-9
- MF: C16H14F3IN2O4
- MW: 482.19
- EINECS:687-152-7
- MDL Number:MFCD08435926
- Synonyms:N-[(2R)-2,3-DIHYDROXYPROPOXY]-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-BENZAMIDE;PD 0325901;(R)-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzamide;PD-0235901;N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)aMino]be;N-[(R)-2,3 -Dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodo-phenylaMino)-benzaMide;N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide PD0325901;PD 0325901 N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
4 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberPZ0162
- Product descriptionPD 0325901 ≥98% (HPLC)
- Packaging5MG
- Price₹15891.1
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number444968
- Product descriptionInSolution MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9 - Calbiochem The InSolution MEK1/2 Inhibitor III, PD0325901, also referenced under CAS 391210-10-9, controls the biological activity of MEK1/2. This small molecule
- Packaging5MG
- Price₹17860
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number444966
- Product descriptionMEK1/2 Inhibitor III - CAS 391210-10-9 - Calbiochem The MEK1/2 Inhibitor III, also referenced under CAS 391210-10-9, controls the biological activity of MEK1/2. This small molecule/inhibitor is primaril
- Packaging5MG
- Price₹23160
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberPZ0162
- Product descriptionPD 0325901 ≥98% (HPLC)
- Packaging25MG
- Price₹60457.63
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | PZ0162 | PD 0325901 ≥98% (HPLC) | 5MG | ₹15891.1 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 444968 | InSolution MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9 - Calbiochem The InSolution MEK1/2 Inhibitor III, PD0325901, also referenced under CAS 391210-10-9, controls the biological activity of MEK1/2. This small molecule | 5MG | ₹17860 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 444966 | MEK1/2 Inhibitor III - CAS 391210-10-9 - Calbiochem The MEK1/2 Inhibitor III, also referenced under CAS 391210-10-9, controls the biological activity of MEK1/2. This small molecule/inhibitor is primaril | 5MG | ₹23160 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | PZ0162 | PD 0325901 ≥98% (HPLC) | 25MG | ₹60457.63 | 2022-06-14 | Buy |
Properties
Melting point :112-114°C
Density :1.817±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :White to off-white solid
pka :13.45±0.20(Predicted)
color :white to off-white
optical activity :[α]/D -1.8 to -3.5°, c = 1 mg/mL in methanol
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey :SUDAHWBOROXANE-SECBINFHSA-N
Density :1.817±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :White to off-white solid
pka :13.45±0.20(Predicted)
color :white to off-white
optical activity :[α]/D -1.8 to -3.5°, c = 1 mg/mL in methanol
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey :SUDAHWBOROXANE-SECBINFHSA-N
Safety Information
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Description
The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. PD 0325901 is a potent MEK inhibitor that suppresses phosphorylation of ERK in mouse colon 26 tumors with an IC50 value of 0.33 nM. Suppression of ERK activation with 1 μM PD 0325901 combined with 3 μM CHIR99021 (a glycogen synthase kinase 3 inhibitor) prevents cell differentiation and sustains self renewal of mouse embryonic stem cells for at least eight passages.Related product price
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