PFI3
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- ₹11821.5 - ₹47696.7
- Product name: PFI3
- CAS: 1819363-80-8
- MF: C19H19N3O2
- MW: 321.37
- EINECS:
- MDL Number:MFCD28100807
- Synonyms:PFI3;PFI-3;(E)-1-(2-Hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one;(2E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-(2-pyridinyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]-2-propen-1-one;PFI3; PFI 3;CS-1803;(2E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]prop-2-en-1-one;2-Propen-1-one, 1-(2-hydroxyphenyl)-3-[(1R,4R)-5-(2-pyridinyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]-, (2E)-
2 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0939
- Product descriptionPFI-3 ≥98% (HPLC)
- Packaging25MG
- Price₹47696.7
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0939
- Product descriptionPFI-3 ≥98% (HPLC)
- Packaging5MG
- Price₹11821.5
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | SML0939 | PFI-3 ≥98% (HPLC) | 25MG | ₹47696.7 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML0939 | PFI-3 ≥98% (HPLC) | 5MG | ₹11821.5 | 2022-06-14 | Buy |
Properties
storage temp. :2-8°C
solubility :Soluble in DMSO (>25 mg/ml)
form :powder
color :yellow to orange
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
solubility :Soluble in DMSO (>25 mg/ml)
form :powder
color :yellow to orange
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Safety Information
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Description
The SWI/SNF-related, Matrix-associated, Actin-dependent Regulator of Chromatin (SMARC) proteins integrate into complexes that remodel chromatin. The SMARC family A (SMARCA) members SMARCA2 (also known as BRM) and SMARCA4 (BRG1) are helicases that contain structurally-related bromodomains for binding acetylated lysine residues on target proteins. The protein polybromo-1 (PB1, BRG1-associated factor) contains six bromodomains, but only the fifth (PB1(5)) shares the same structural signature as those of SMARCA2 and SMARCA4. PFI-3 is a probe that binds avidly to the structurally-similar SMARCA4 bromodomain and PB1(bromodomain 5) with Kd values of 89 and 48 nM, respectively. Evaluation of interactions of PFI-3 with different classes of bromodomains using thermal stability assay indicates that PFI-3 interacts selectively with bromodomains from SMARCA2 and SMARCA4 as well as the fifth domain of PB1. Similarly, PFI-1 does not interact with a panel of kinases. See the Structural Genomics Consortium (SGC) website for more information.Related product price
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