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VU0456810

VU0456810 Structure
  • ₹11550.28 - ₹46558.33
  • Product name: VU0456810
  • CAS: 1443246-62-5
  • MF: C17H14F2N4O
  • MW: 328.32
  • EINECS:
  • MDL Number:MFCD27977571
  • Synonyms:1-(3,4-Difluorophenyl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea;CID 56642816;ML297;VU0456810;1-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA;ML297, Pubchem: CID 56642816;ML297 (VU0456810);ML 297;ML-297;ML297;VU0456810;VU-0456810;VU 0456810
Price3 Properties Safety Information Description
3 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 10MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0836
  • Product descriptionML297 ≥98% (HPLC)
  • Packaging5MG
  • Price₹11550.28
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number5.05820
  • Product descriptionGIRK Activator, ML297 - CAS 1443246-62-5 - Calbiochem
  • Packaging10MG
  • Price₹21209.99
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0836
  • Product descriptionML297 ≥98% (HPLC)
  • Packaging25MG
  • Price₹46558.33
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML0836 ML297 ≥98% (HPLC) 5MG ₹11550.28 2022-06-14 Buy
Sigma-Aldrich(India) 5.05820 GIRK Activator, ML297 - CAS 1443246-62-5 - Calbiochem 10MG ₹21209.99 2022-06-14 Buy
Sigma-Aldrich(India) SML0836 ML297 ≥98% (HPLC) 25MG ₹46558.33 2022-06-14 Buy

Properties

Boiling point :377.8±42.0 °C(Predicted)
Density :1.32±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: soluble15mg/mL, clear
pka :12.54±0.70(Predicted)
form :White powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.
P501 Dispose of contents/container to..…

Description

G protein-regulated inwardly rectifying potassium (GIRK1-4) channels are a family of Kir3.1-Kir3.4 ion channels that modulate cell excitability. The four different GIRK subunits are composed in different homo- and heterotetrameric combinations, which are expressed with regional specificity throughout the central nervous system and in the periphery. ML-297 is a selective GIRK1/2 activator (EC50s = 0.16 and 1.8 μM for GIRK1/2 and GIRK1/4, respectively, and is completely inactive at GIRK2/3). In two different mouse models of epilepsy, ML-297 at 60 mg/kg was shown to delay seizure onset and to prevent convulsions.

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