XL019
- ₹7230 - ₹29170
- Product name: XL019
- CAS: 945755-56-6
- MF: C25H28N6O2
- MW: 444.53
- EINECS:-0
- MDL Number:MFCD24386874
- Synonyms:2S)-N-[4-[2-[[4-(4-Morpholinyl)phenyl]amino]-4-pyrimidinyl]phenyl]-2-pyrrolidinecarboxamide XL019;XL019 2-Pyrrolidinecarboxamide, N-[4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]phenyl]-, (2S)-;Pyrrolidine-2-carboxylic acid {4-[2-(4-morpholin-4-yl-phenylamino)-pyrimidin-4-yl]-phenyl}-amide;XL019, >=98%;XL019;XL019/XL-019;(2S)-N-[4-[2-[[4-(4-Morpholinyl)phenyl]amino]-4-pyrimidinyl]phenyl]-2-pyrrolidinecarboxamide;(S)-N-(4-(2-(4-MORPHOLINOPHENYLAMINO)PYRIMIDIN-4-YL)PHENYL)PYRROLIDINE-2-CARBOXAMIDE
2 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML2393
- Product descriptionXL019 ≥98% (HPLC)
- Packaging25MG
- Price₹29170
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML2393
- Product descriptionXL019 ≥98% (HPLC)
- Packaging5MG
- Price₹7230
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | SML2393 | XL019 ≥98% (HPLC) | 25MG | ₹29170 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML2393 | XL019 ≥98% (HPLC) | 5MG | ₹7230 | 2022-06-14 | Buy |
Properties
storage temp. :Store at -20°C
solubility :insoluble in EtOH; insoluble in H2O; ≥11.125 mg/mL in DMSO
form :solid
color :Green to yellow
solubility :insoluble in EtOH; insoluble in H2O; ≥11.125 mg/mL in DMSO
form :solid
color :Green to yellow
Safety Information
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Description
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 where a switch from valine to phenylalanine occurs at the 617 position (V617F). Furthermore, constitutive activation of the JAK2 signaling pathway is associated with aggressive adult T cell leukemia/lymphoma. XL019 is a potent, bioavailable JAK inhibitor with preference for JAK2 (IC50 = 2 nM) over JAK1 and JAK3 (IC50s = 130 and 250 nM, respectively). It is effective against JAK2V617F as well as JAK2 and inhibits phosphorylation of STAT5 in vivo.More related product prices
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