PROTRIPTYLINE
- CAS No.
- 438-60-8
- Chemical Name:
- PROTRIPTYLINE
- Synonyms
- Triptil;Vivactil;Amimetilina;Protriptylin;PROTRIPTYLINE;Protryptyline;Protriptyline-d6;Protriptyline 13CD3;DIBENZO(A,D)CYCLOHEPTENE-5-PROPYLAMINE,N-METHYL-;3-(dibenzo(a,d)cyclohepten-5-yl)propylmethylamine
- CBNumber:
- CB0774981
- Molecular Formula:
- C19H21N
- Molecular Weight:
- 263.38
- MOL File:
- 438-60-8.mol
- Modify Date:
- 2023/5/4 17:34:38
| Boiling point | 396.62°C (rough estimate) |
|---|---|
| Density | 0.9076 (rough estimate) |
| refractive index | 1.7500 (estimate) |
| pka | 8.2(at 25℃) |
| EPA Substance Registry System | Protriptyline (438-60-8) |
PROTRIPTYLINE Chemical Properties,Uses,Production
Uses
Protriptyline is a powerful antidepressant, the mechanism of action of which is not known. It is not a MAO inhibitor and does not stimulate the CNS. It begins to act much faster and acts much longer than imipramine or amitriptyline. Protriptyline does not possess sedative tranquilizing properties. It is used in clinical conditions for treating severe depression.
Mechanism of action
Protriptyline exhibits high selectivity for the NE transporter, but with less potency than desipramine. Its mechanism of action is similar to that of desipramine. Minimal effect on 5-HT reuptake has been observed.
Metabolism
Protriptyline is a dibenzocycloheptriene TCA that differs from the other tricyclics by having an unsaturated ethylene bridge joining the two aromatic rings and a secondary aminopropyl side chain. Protriptyline is completely absorbed from the GI tract and slowly eliminated. Metabolism data are limited for protriptyline, but it is most likely to be metabolized via the same pathways as the other TCAs are. Very little drug is excreted in the feces via the bile.
PROTRIPTYLINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| RXN Chemicals Private Limited | 08069013898Ext 881 | Mumbai, India | 137 | 58 | Inquiry |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | China | 9003 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 4008200310 | China | 24017 | 58 | Inquiry |
| Nanjing Shizhou Biology Technology Co.,Ltd | 17301488900 | China | 12584 | 58 | Inquiry |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 17691182729 18161915376 | China | 10011 | 58 | Inquiry |
| BOSCHE SCIENTIFIC, LLC | 732 565 9988 | United States | 6486 | 55 | Inquiry |
| ChemPacific Corporation | 410 633 5771 | United States | 6902 | 51 | Inquiry |