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BNP-32 (HUMAN)

CAS No.: 124584-08-3

Chemical Name:: BNP-32 (HUMAN)

Synonyms: BNP HUMAN;Nesiritide;BNP-32 (HUMAN);Nesiritide TFA;BNP (1-32), HUMAN;Nesiritide (BNP-32);Brain natriuretic pe;Nesiritide [USAN:INN];BNP-32 (HUMAN) USP/EP/BP;BNP-32 (human) hydrochloride

CBNumber:: CB1676347

Molecular Formula:: C143H244N50O42S4

Molecular Weight:: 3464.05

MOL File:: 124584-08-3.mol

Modify Date:: 2024/7/2 8:55:01

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BNP-32 (HUMAN) Properties

Density	1.52±0.1 g/cm3(Predicted)
RTECS	EE1534000
storage temp.	−20°C
form	powder
color	White to off-white
Water Solubility	Soluble in water at 1mg/ml
Sequence	H-Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His-OH(Disulfide bridge: Cys10-Cys26)
CAS DataBase Reference	124584-08-3

SAFETY

Risk and Safety Statements

WGK Germany	3

BNP-32 (HUMAN) price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	B5900	Brain Natriuretic Peptide-32 human ≥97% (HPLC), powder	124584-08-3	0.5MG	₹50347.08	2022-06-14	Buy
Sigma-Aldrich(India)	B5900	Brain Natriuretic Peptide-32 human ≥97% (HPLC), powder	124584-08-3	1MG	₹90237.2	2022-06-14	Buy

Product number	Packaging	Price	Buy
B5900	0.5MG	₹50347.08	Buy
B5900	1MG	₹90237.2	Buy

BNP-32 (HUMAN) Chemical Properties,Uses,Production

Description

Nesiritide was introduced in the US as a new intravenous treatment for patients with acutely decompensated congestive heart failure who have dyspnea at rest or with minimal activity. Nesiritide is the first human recombinant form of the potent vasodilatory B-type natriuretic peptide (also known as brain natriuretic peptide), a naturally occurring 32 amino acid peptide with a disulfide-bonded 17 amino acid ring structure. Nesiritide binds to the Atype natriuretic peptide receptor on the surface of endothelial and smooth muscle cells stimulating production of the second messenger cGMP which mediates predominantly vascular smooth muscle cell relaxation. It also facilitates the elimination of sodium and water by the kidney and decreases the secretion of certain hormones, such as adrenalin, angiotensin II, aldosterone and endothelin, which provoke long-term detrimental effects including blood vessel constriction and blood pressure elevation. In clinical trials with heart failure patients, nesidtide dose-dependently reduced pulmonary capillary wedge pressure, right atrial pressure and systemic vascular resistance and increased cardiac index without affecting heart rate. The major adverse effect observed was dose-dependent hypotension. In a phase III comparative trial, nesiritide was found to be superior to iv. nitroglycerine in its haemodynamic effects as well as easier to administer and better tolerated. Nesiritide is cleared by proteolytic cleavage by the enzyme neutral endopeptidase NEP24.11 and by binding to the C-type natriuretic peptide receptor followed by endocytosis and intracellular lysosomal hydrolysis. Since it has a short half-life (18 min), nesiritide is administered as a 21μg/kg bolus infusion followed by a continuous maintenance infusion at 0.011μg/kg/min usually over 24-48 hours.

Uses

Treatment of congestive heart failure (renin-angiotensin system antagonist).

General Description

The gene encoding brain natriuretic peptide-32 (BNP-32) is localized on human chromosome 1p36.22. It is implicated in several biological functions such as diuresis, natriuresis, hypotensive action and inhibition of aldosterone secretion. BNP-32 acts as a potential biomarker of high left ventricular-diastolic pressure in patients with symptomatic left ventricular (LV) dysfunction. Elevated expression of this protein is observed in acute myocardial infarction (AMI) patients.

BNP-32 (HUMAN) Preparation Products And Raw materials

Raw materials

Preparation Products

BNP-32 (HUMAN) Suppliers

Global( 107)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	China	988	58	Inquiry
Alpha Biopharmaceuticals Co., Ltd	+86-15542445688	China	888	58	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21667	55	Inquiry
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	China	10311	58	Inquiry
Cellmano Biotech Limited	0551-65326643 18156095617	China	999	58	Inquiry
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	China	10297	58	Inquiry
Hebei Yanxi Chemical Co., Ltd.	+86-17531190177; +8617531190177	China	5873	58	Inquiry
Hubei Ipure Biology Co., Ltd	+8613367258412	China	10326	58	Inquiry
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	China	30250	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	24200	58	Inquiry

Supplier	Advantage
Sinoway Industrial co., ltd.	58
Alpha Biopharmaceuticals Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Shenzhen Nexconn Pharmatechs Ltd	58
Cellmano Biotech Limited	58
Fuxin Pharmaceutical	58
Hebei Yanxi Chemical Co., Ltd.	58
Hubei Ipure Biology Co., Ltd	58
Career Henan Chemica Co	58
Dideu Industries Group Limited	58

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Nesiritide [USAN:INN] SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH (DISULFIDE BRIDGE: 10-26) SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS H-SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS-OH H-SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS-OH (DISULFIDE BRIDGE: 10-26) BRAIN NATRIURETIC PEPTIDE (1-32), HUMAN BRAIN(B-TYPE) NATRIURETIC PEPTIDE-32 (HUMAN) BRAIN NATRIURETIC PEPTIDE, HUMAN BRAIN NATRIURETIC PEPTIDE-32 (HUMAN) B-TYPE (BRAIN) NATRIURETIC PEPTIDE-32 (HUMAN) BNP HUMAN BNP-32 (HUMAN) BNP (1-32), HUMAN BNP-32 (huMan) Brain Natriuretic Peptide-32 (huMan), Nesiritide Brain Natriuretic Peptide-32 (huMan), Nesiritide H-Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His-OH Acetate salt (Disulfide bond) Nesiritide Nesiritide,Brain Natriuretic Peptide-32 human,BNP-32, >98% BNP-32 (human) hydrochloride Nesiritide (BNP-32) Brain Natriuretic Peptide (BNP) (1-32), human L-Histidine, L-seryl-L-prolyl-L-lysyl-L-methionyl-L-valyl-L-glutaminylglycyl-L-serylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-arginyl-L-lysyl-L-methionyl-L-α-aspartyl-L-arginyl-L-isoleucyl-L-seryl-L-seryl-L-seryl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-lysyl-L-valyl-L-leucyl-L-arginyl-L-arginyl-,... BNP-32 (HUMAN) USP/EP/BP Brain natriuretic pe 124584-08-3 Nesiritide [USAN:INN] Nesiritide，Brain Natriuretic Peptide-32 human，BNP-32 Nesiritide TFA L-Histidine, L-seryl-L-prolyl-L-lysyl-L-methionyl-L-valyl-L-glutaminylglycyl-L-serylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-arginyl-L-lysyl-L-methionyl-L-α-aspartyl-L-arginyl-L-isoleucyl-L-seryl-L-seryl-L-seryl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-lysyl-L-valyl-L-leucyl-L-arginyl-L-arginyl-, cyclic (10→26)-disulfide 124584-08-3 C143H224N50O42S4 Peptides Natriuretic Peptides Amino Acids and Peptides BioChemical Biochemicals and Reagents Elisa Kit-Mouse Elisa Kit