ChemicalBook > Product Catalog >API >Circulatory system drugs >Anti Shock vasoactive drugs >Dobutamine hydrochloride
Dobutamine hydrochloride
- CAS No.
- 49745-95-1
- Chemical Name:
- Dobutamine hydrochloride
- Synonyms
- DOBUTAMINE HCL;Dobutrex;46236;Dobux;Dopmin;Inotrex;NSC 299583;Dobutamine hydrochlo;Dobutamine hydrochloride;DL-Dobutamine hydrochloride
- CBNumber:
- CB8274063
- Molecular Formula:
- C18H24ClNO3
- Molecular Weight:
- 337.84
- MOL File:
- 49745-95-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:23
| Melting point | 184-186 C |
|---|---|
| storage temp. | 2-8°C |
| solubility | Sparingly soluble in water, soluble in methanol, sparingly soluble in ethanol (96 per cent). |
| form | Solid |
| pka | 9.45(at 25℃) |
| color | White to Off-White |
| Water Solubility | Soluble in water or ethanol with warming. Also soluble in methanol |
| λmax | 281nm(MeOH)(lit.) |
| Merck | 14,3395 |
| Stability | Solutions are rapidly oxidized at pH 11-13. It is recommended that solutions be freshly prepared and protected from light. Dobutamine hydrochloride is sensitive to light. |
| CAS DataBase Reference | 49745-95-1(CAS DataBase Reference) |
| EPA Substance Registry System | 1,2-Benzenediol, 4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-, hydrochloride (49745-95-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H361 | |||||||||
| Precautionary statements | P201-P280-P301+P312+P330-P302+P352+P312-P304+P340+P312-P308+P313 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 20/21/22-63-36/37/38-R63-R62-R11-R21-R20 | |||||||||
| Safety Statements | 22-26-36/37/39-36/37-S53-S39-S37-S36-S26-S22 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29222990 | |||||||||
| Toxicity | LD50 i.v. in mice: ~73 mg/kg (Weber, Tuttle) | |||||||||
| NFPA 704 |
|
Dobutamine hydrochloride price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D0676 | Dobutamine hydrochloride ≥98% | 49745-95-1 | 10MG | ₹9006.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D0676 | Dobutamine hydrochloride ≥98% | 49745-95-1 | 50MG | ₹27094.98 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D4335 | Dobutamine Hydrochloride | 49745-95-1 | 20MG | ₹3400 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D4335 | Dobutamine Hydrochloride | 49745-95-1 | 100MG | ₹10800 | 2022-05-26 | Buy |
Dobutamine hydrochloride Chemical Properties,Uses,Production
Description
Dobutamine hydrochloride, a dopamine derivative, is a selective β1-adrenergic agonist. It is a sympathomimetic agent with inotropic action (changes strength of muscle contraction) on the heart. However, it may have some α and β2-agonist properties as well.The active substance strengthens the contraction power of the heart, increases the stroke volume and thus the blood circulation of the organs. It is used for the treatment of acute heart failure and for cardiac stress tests.
Chemical Properties
Dobutamine hydrochloride occurs as a white to off-white crystalline powder, which is sparingly soluble in water and in alcohol. Dobutamine has a pKa of 9.4.
Uses
Dobutamine Hydrochloride is a sympathomimetic drug used to treat heart failure by inhibiting β1 receptors in the sympathetic nervous system. Cardiotonic.
Definition
ChEBI: The hydrochloride salt of dobutamine. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used to increase the contractility of the heart in the m nagement of acute heart failure.
Biological Activity
β 1 - and β 2 -adrenoceptor agonist with some action at the α 1 -adrenoceptor.
Dobutamine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 312)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| PANCHSHEEL ORGANICS LTD | +91-9821053955 +91-9324201019 | Mumbai, India | 82 | 58 | Inquiry |
| DK Pharmachem Pvt Ltd | +91-2242153111 +91-2242153111 | Maharashtra, India | 37 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Suvan LifeSciences (formerly Sansh Biotech Pvt Ltd) | +91-1142631798 +91-9899000024 | New Delhi, India | 55 | 58 | Inquiry |
| Venture Pharmaceuticals pvt ltd | +91-9173909075 +91-9173909075 | Gujarat, India | 45 | 58 | Inquiry |
| Indo China Pharma Co., | +91 22 6534 0500 | Mumbai, India | 11 | 58 | Inquiry |
| SPB Pharma Chiemimpex | 91-9043046289 | Tamil Nadu, India | 94 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Pharmaffiliates Analytics & Synthetics (P) Ltd. | 91-172-5066494 | Haryana, India | 631 | 58 | Inquiry |
| Shagun Pharmaceuticals | 91-731-2575029 | Madhya Pradesh, India | 193 | 58 | Inquiry |
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Dobutamine hydrochloride
CAS49745-95-1 DOBUTAMINE HYDROCHLORIDE
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49745-95-1
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Adrenoceptor
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