Michler's ketone
![Michler's ketone Structure](CAS/GIF/90-94-8.gif)
- CAS No.
- 90-94-8
- Chemical Name:
- Michler's ketone
- Synonyms
- Bis(4-(dimethylamino)phenyl)methanone;BIS-DIMETHYLAMINOPHENYLMETHANONE;MICHLERS KETONE;nsc9602;ai3-22412;michler’s;NCI-C02006;Ketone base;MICHLER KETONE;MICHLER'S KETONE
- CBNumber:
- CB1703263
- Molecular Formula:
- C17H20N2O
- Molecular Weight:
- 268.35
- MOL File:
- 90-94-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/14 15:18:25
Melting point | 174 -176 °C(lit.) |
---|---|
Boiling point | 360 °C |
Density | 1.0208 (rough estimate) |
refractive index | 1.5486 (estimate) |
Flash point | 220 °C |
storage temp. | Store below +30°C. |
solubility | ethanol: 5 mg/mL, clear |
form | Powder |
pka | 2.55±0.12(Predicted) |
color | Blue to dark blue or gray |
Water Solubility | 400 mg/L (20 ºC) |
Merck | 14,6177 |
BRN | 790733 |
Stability | Stable. Combustible. Incompatible with strong oxidizing agents, strong reducing agents. |
InChIKey | VVBLNCFGVYUYGU-UHFFFAOYSA-N |
CAS DataBase Reference | 90-94-8(CAS DataBase Reference) |
IARC | 2B (Vol. 99) 2010 |
NIST Chemistry Reference | Methanone, bis[4-(dimethylamino)phenyl]-(90-94-8) |
EPA Substance Registry System | Michler's ketone (90-94-8) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() GHS05,GHS08 |
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Signal word | Danger | |||||||||
Hazard statements | H318-H341-H350 | |||||||||
Precautionary statements | P201-P280-P305+P351+P338+P310-P308+P313 | |||||||||
Hazard Codes | T,Xi | |||||||||
Risk Statements | 45-41-68-36/37/38 | |||||||||
Safety Statements | 53-45-36-26 | |||||||||
RIDADR | 2811 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | DJ0250000 | |||||||||
Autoignition Temperature | 480 °C | |||||||||
TSCA | Yes | |||||||||
HazardClass | 6.1 | |||||||||
PackingGroup | III | |||||||||
HS Code | 29223990 | |||||||||
Toxicity | LD50 orally in Rabbit: > 6400 mg/kg | |||||||||
NFPA 704 |
|
Michler's ketone price More Price(8)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 8.08125 | 4,4′-Bis(dimethylamino)-benzophenone for synthesis | 90-94-8 | 250G | ₹7600.01 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 8.08125 | 4,4′-Bis(dimethylamino)-benzophenone for synthesis | 90-94-8 | 1KG | ₹18180 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 56614 | Michler′s ketone certified reference material, TraceCERT? | 90-94-8 | 100MG | ₹8844.03 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 147834 | Michler′s ketone 98% | 90-94-8 | 100G | ₹2998.53 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 147834 | Michler′s ketone 98% | 90-94-8 | 500G | ₹6960.48 | 2022-06-14 | Buy |
Michler's ketone Chemical Properties,Uses,Production
Chemical Properties
white to light greenish crystals
Uses
In manufacture of dyes and pigments.
General Description
White to greenish crystalline leaflets or blue powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
4,4'-Bis(dimethylamino)benzophenone is incompatible with strong oxidizing agents and strong reducing agents .
Hazard
Possible carcinogen.
Fire Hazard
Literature sources indicate that 4,4'-Bis(dimethylamino)benzophenone is combustible.
Safety Profile
Confirmed human carcinogen with experimental carcinogenic and neoplastigenic data. A poison by ingestion. Mutation data reported. A flammable liquid. When heated to decomposition it emits toxic fumes of NOx.
Potential Exposure
Mutagen. Animal Carcinogen. Michler’s ketone is a dye intermediate and derivative of dimethylaniline. It is also used in antifreeze formulations, cosmetics, cleaning compounds; heat transfer fluids; as a chemical intermediate in the synthesis of at least 13 dyes and pigments, especially auramine derivatives.
Carcinogenicity
Michler’s ketone is reasonably anticipated to be a human cagen based on sufficient evidence of carcinogenicity from stud rcinoies in experimental animals.
Shipping
UN3143 Dyes, solid, toxic, n.o.s. or Dye intermediates, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poison Inhalation Hazard. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN1602 Dyes, liquid, toxic, n.o.s or Dye intermediates, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Purification Methods
Dissolve the ketone in dilute HCl, filter and precipitate it by adding ammonia (to remove water-insoluble impurities such as benzophenone). Then crystallise it from EtOH or pet ether. [Suppan J Chem Soc, Faraday Trans1 71 539 1975.] It is also purified by dissolving in *benzene, then washing with water until the aqueous phase is colourless. The *benzene is evaporated off, and the residue is recrystallised three times from *benzene and EtOH [Hoshino & Kogure J Phys Chem 72 417 1988]. [Beilstein 14 IV 255.]
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from aldehydes, alkaline materials, strong acids, strong bases, strong reducing agents such as hydrideds and active metals. Contact with hydrogen peroxide may form heat- and shock- sensitive explosives.
Waste Disposal
Do not discharge into drains or sewers. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. If allowed, Incineration with effluent gas scrubbing is recommended. Containers must be disposed of properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.
Michler's ketone Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
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chevron_rightSupplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
Chemosol Inds. (India) Private Limited | +91 22 - 2341 1018 | Mumbai, India | 25 | 58 | Inquiry |
Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
HiMedia Laboratories | 91-22-61471919 | Maharashtra, India | 1843 | 58 | Inquiry |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12447 | 58 | Inquiry |
Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | China | 5873 | 58 | Inquiry |
Supplier | Advantage |
---|---|
CLEARSYNTH LABS LTD. | 58 |
CHEMSWORTH | 30 |
A.J Chemicals | 58 |
TCI Chemicals (India) Pvt. Ltd. | 58 |
Alfa Aesar | 58 |
Chemosol Inds. (India) Private Limited | 58 |
Clearsynth Labs | 58 |
HiMedia Laboratories | 58 |
Hebei Mojin Biotechnology Co., Ltd | 58 |
Hebei Yanxi Chemical Co., Ltd. | 58 |
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