Primidone
- CAS No.
- 125-33-7
- Chemical Name:
- Primidone
- Synonyms
- Cyral;Sertan;roe101;Midone;Roe 101;Mizodin;Mizolin;Mysedon;Misoline;Mizoline
- CBNumber:
- CB1161900
- Molecular Formula:
- C12H14N2O2
- Molecular Weight:
- 218.25
- MOL File:
- 125-33-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:00
| Melting point | 281-282°C |
|---|---|
| Boiling point | 358.94°C (rough estimate) |
| Density | 1.1402 (rough estimate) |
| refractive index | 1.6660 (estimate) |
| Flash point | 9℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Very slightly soluble in water, slightly soluble in ethanol (96 per cent). It dissolves in alkaline solutions. |
| form | Solid |
| pka | 12.26±0.40(Predicted) |
| color | White to Off-White |
| Water Solubility | <0.1 g/100 mL at 19 ºC |
| Merck | 14,7746 |
| BCS Class | 2 |
| InChIKey | DQMZLTXERSFNPB-UHFFFAOYSA-N |
| CAS DataBase Reference | 125-33-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Primidone(125-33-7) |
| IARC | 2B (Vol. 108) 2016 |
| EPA Substance Registry System | Primidone (125-33-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H351-H361d | |||||||||
| Precautionary statements | P201-P202-P264-P270-P301+P312-P308+P313 | |||||||||
| Hazard Codes | Xn,T,F | |||||||||
| Risk Statements | 22-40-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 22-36-45-36/37-16-7 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UV9100000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29335990 | |||||||||
| Toxicity | child,TDLo,oral,625mg/kg (625mg/kg),BEHAVIORAL: SLEEPBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)BEHAVIORAL: GENERAL ANESTHETIC,British Medical Journal. Vol. 1, Pg. 90, 1957. | |||||||||
| NFPA 704 |
|
Primidone price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR3109 | Primidone pharmaceutical secondary standard, certified reference material | 125-33-7 | 500MG | ₹18380.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P7295 | Primidone analytical standard | 125-33-7 | 5G | ₹5639.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P-075 | Primidone solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? | 125-33-7 | 1ML | ₹7248.5 | 2022-06-14 | Buy |
| TCI Chemicals (India) | P1906 | Primidone | 125-33-7 | 5G | ₹3600 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P1906 | Primidone | 125-33-7 | 25G | ₹8700 | 2022-05-26 | Buy |
Primidone Chemical Properties,Uses,Production
Description
Primidone is chemically and structurally similar to phenobarbital with the exception that the carbonyl group on C2 is replaced by a methylene group. This modification leads to the production of a drug with strong anticonvulsant properties without expressed soporific effects.
Chemical Properties
Crystalline Solid
Uses
Primidone is mainly used for major attacks.
Definition
ChEBI: A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.
General Description
Odorless white crystalline powder. Slightly bitter taste. No acidic properties.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Primidone is an amide. May react with azo and diazo compounds to generate toxic gases. May react with strong reducing agents to form flammable gases. A very weak base. The Combustion generates toxic mixed oxides of nitrogen (NOx).
Fire Hazard
Flash point data for Primidone are not available; however, Primidone is probably combustible.
Biological Activity
Anticonvulsant.
Clinical Use
Primidone is the 2-deoxy derivative of phenobarbital and is approved by the U.S. FDA for initial or adjunctive treatment of simple partial, complex partial, and tonic-clonic seizures. It is less effective against these types of seizures than is phenytoin or CBZ, and it shares the antiseizure and sedative actions of phenobarbital. Although not approved for the purpose, it often is used to treat benign familial tremor (essential tremor).
Side effects
As with phenobarbital, serious toxicity for primidone is rare, although it may cause disabling sedation, irritability, and decreased mental functioning in a number of persons. Ataxia, dysphoria, idiosyncratic rash, leukopenia, agranulocytosis, lymphadenopathy, hepatitis, and a systemic lupus erythematosus–like syndrome have been reported adverse effects for primidone. Deficiencies of folic acid and of vitamins D and K are possible with long-term therapy of primidone, as is a folateresponsive megaloblastic anemia. Measurement of the complete blood cell count should be performed at 6-month intervals.
Safety Profile
Poison by ingestion and intraperitoneal routes. Human teratogenic effects include developmental abnormalities of the craniofacial area, skin and skin appendages, and cardlovascular system. Human reproductive effects: effects on newborn, including unusual growth statistics, drug dependence, physical and other neonatal changes. Experimental teratogenic and reproductive effects. Human mutation data reported. An addictive drug. When heated to decomposition it emits toxic fumes of NOx. See also BARBITURATES.
Primidone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Basil Drugs AND Pharmaceuticals Pvt Ltd | +91-2249700250 +91-9619320820 | Mumbai, India | 108 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| ProVentus Life Sciences Pvt Ltd | +91-4428362047 +91-4447400141 | Tamil Nadu, India | 20 | 58 | Inquiry |
| Biophore India Pharmaceuticals Pvt Ltd | +91-9100031592 +91-9030907714 | Telangana, India | 134 | 58 | Inquiry |
| Shruti Drugs Pvt., Ltd. | 91-40-27544507 | Telangana, India | 13 | 58 | Inquiry |
| Zyden Gentec Limited | +91 (0) 845 827 9815 | Rajasthan, India | 6 | 58 | Inquiry |
| Merit International | 91-22-40150081 | Maharashtra, India | 226 | 58 | Inquiry |
| Sai Prathyu Marketing | 91-9666672409 | Hyderabad, India | 162 | 58 | Inquiry |
| ProVentus Life Sciences Private Limited | +91 44 47400141 | Tamil Nadu, India | 3 | 58 | Inquiry |
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