Acamprosate calcium
- CAS No.
- 77337-73-6
- Chemical Name:
- Acamprosate calcium
- Synonyms
- Aotal;CaAOTA;AlcoMed;Sobriol;CaMpral EC;trans-N-Boc-1;2R)-trans-N-Boc-1;ALAMPROSATECALCIUM;ACAMPROSATE CALCIUM;CalciuM AcaMprosate
- CBNumber:
- CB4310705
- Molecular Formula:
- C10H20CaN2O8S2
- Molecular Weight:
- 400.48
- MOL File:
- 77337-73-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/20 16:43:00
| Melting point | >300°C |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: >5mg/mL |
| form | powder |
| color | White to Off-White |
| Water Solubility | Soluble in water (100mM) |
| Merck | 14,17 |
| CAS DataBase Reference | 77337-73-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P305+P351+P338-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TZ6357000 | |||||||||
| HS Code | 29241990 | |||||||||
| Toxicity | LD50 i.p. in male mice: 1.87 g/kg (Durlach, 1982) | |||||||||
| NFPA 704 |
|
Acamprosate calcium price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A6981 | Acamprosate calcium ≥98% (HPLC), powder | 77337-73-6 | 10MG | ₹13834.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A6981 | Acamprosate calcium ≥98% (HPLC), powder | 77337-73-6 | 50MG | ₹55369.88 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A2359 | Acamprosate Calcium | 77337-73-6 | 1G | ₹14200 | 2022-05-26 | Buy |
Acamprosate calcium Chemical Properties,Uses,Production
Description
Acamprosate is an acetylated derivative of the GABA analog homotaurine (tramiprosate; ). Despite its structural similarity to GABA, acamprosate does not act at GABAA receptors but does decrease paired-pulse inhibition of GABAA inhibitory post-synaptic currents (IPSCs) at short inter-stimulus intervals when used at a concentration of 300 μM, indicating that it may inhibit GABAB autoreceptor-mediated inhibition of GABA release. It is an NMDA receptor modulator with antagonist or agonist effects depending on brain region, receptor subunit composition, and other factors. Acamprosate (0.26 and 0.52 mmol/kg per day, i.p.) reduces voluntary intake of ethanol in rats, an effect that can be blocked by the GABA antagonist bicuculline . Formulations containing acamprosate have been used for the maintenance of alcohol abstinence.
Chemical Properties
Acamprosate calcium is White Crystalline Solid
Uses
Acamprosate calcium is a synthetic amino acid and a neurotransmitter analogue that is used as an alcohol deterrent in management of alcohol dependence and abuse. Acamprosate calcium was approved for use in the therapy of alcohol dependence and abuse in the United States in 2004.
Biological Activity
GABA receptor agonist and modulator of glutamatergic systems. Reduces alcohol consumption in animal models of alcohol addiction.
Acamprosate calcium Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Global Pharma | +91-9819994077 +91-9819994077 | Maharashtra, India | 34 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Brawn Laboratories Limited | +91-01129815331 +91-01129815331 | Haryana, India | 20 | 58 | Inquiry |
| Ind Swift Laboratories Ltd | +91-1126226140 +91-1126226140 | New Delhi, India | 26 | 58 | Inquiry |
| Athos Chemicals | 91-9998858909 | Gujarat, India | 315 | 58 | Inquiry |
| Turakhia Brothers (Panchsheel Organics Limited) | 91-22-22084282 | Maharashtra, India | 55 | 58 | Inquiry |
| Biopharmacule Speciality Chemicals P Ltd (India) | +91 40 6462 1866 | Hyderabad, India | 526 | 58 | Inquiry |
| Ayon PharmaChem | 91-22-28638348 | Maharashtra, India | 303 | 58 | Inquiry |
| Anika International Pvt. Limited | 91-11-47289900 | Delhi, India | 94 | 58 | Inquiry |
| Ind-Swift Laboratories Ltd. | 91-11-26226140 | Delhi, India | 28 | 58 | Inquiry |
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