Chinese english Japanese Germany Korea
ChemicalBook > Product Catalog >API >Antibiotics >Cephalosporins Drugs >Cefroxadine

Cefroxadine

Cefroxadine Structure
CAS No.
51762-05-1
Chemical Name:
Cefroxadine
Synonyms
cxd;C12979;Oraspor;cgp9000;cefroxadin;CEFROXADINE;BRN 0587499;antibioticcgp9000;Cefroxadine. Oraspor;Cefroxadine USP/EP/BP
CBNumber:
CB5191790
Molecular Formula:
C16H19N3O5S
Molecular Weight:
365.4
MOL File:
51762-05-1.mol
Modify Date:
2023/5/4 17:34:39
Request For Quotation

Cefroxadine Properties

Melting point 170° (dec)
alpha D20 +87° (c = 1.093 in 0.1N HCl)
Boiling point 251°C (rough estimate)
Density 1.3163 (rough estimate)
refractive index 1.6390 (estimate)
pka pKa 3.30±0.02(H2O t=35.0 I=0.00)(Approximate)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H334-H317
Precautionary statements  P261-P285-P304+P341-P342+P311-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
Toxicity LD50 in mice (mg/kg): >6000 orally; 7090 i.p. (Scartazzini, Bickel, 1978)

Cefroxadine Chemical Properties,Uses,Production

Description

Cefroxadine was synthesized by Ciba-Geigy in 1972. A methoxyl group replaced the methyl group of cephradine at the 3 position of the cephem nucleus. Cefroxadine shows stronger activities than cephalexin, especially bactericidal and bacteriolytic activities, and it has better oral absorption that is less affected by a recent meal. Cefroxadine shows less renal toxicity than cephalexin in toxicological studies using animals.

Uses

Antibacterial.

Antimicrobial activity

Cefroxadine is closely related to cefradine, the structure differing only by the presence of a methoxy group replacing methyl at the C-3 position. The antimicrobial spectrum is identical to that of cefradine and cefalexin. A dose of 1 g as film-coated tablets produced mean peak plasma levels of 25 mg/L at 1 h. Absorption is depressed and delayed by administration with food. The plasma elimination half-life is 0.8 h, rising to 40 h in end-stage renal failure and falling to 3.4 h during hemodialysis. Around 85% of an oral dose is excreted unchanged in the urine. It is available in Japan.

Cefroxadine Preparation Products And Raw materials

Raw materials

Propylene oxide Sodium hydroxide N,O-Bis(trimethylsilyl)acetamide Phosphorus pentachloride

Preparation Products

Cefroxadine Suppliers

Global( 32)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29900 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Hefei TNJ Chemical Industry Co.,Ltd. 0551-65418671 China 34571 58 Inquiry
Shaanxi Dideu Medichem Co. Ltd +86-029-89586680 +86-18192503167 China 9030 58 Inquiry
AFINE CHEMICALS LIMITED +86-0571-85134551 China 15395 58 Inquiry
BOC Sciences 16314854226; +16314854226 United States 19743 58 Inquiry
changzhou huayang technology co., ltd +8615250961469 China 9821 58 Inquiry
Supplier Advantage
career henan chemical co 58
BOC Sciences 58
Chongqing Chemdad Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
TargetMol Chemicals Inc. 58
Hefei TNJ Chemical Industry Co.,Ltd. 58
Shaanxi Dideu Medichem Co. Ltd 58
AFINE CHEMICALS LIMITED 58
BOC Sciences 58
changzhou huayang technology co., ltd 58

51762-05-1(Cefroxadine)Related Search:

Glycine Ceftriaxone sodium Cefradine CEFTRIAXONE (Trifluoromethoxy)benzene
Cefuroxime sodium Anisole Molasses Acetyl coenzyme A sodium salt ALTRENOGEST
Ceftazidime Cephalexin Cefixime Cefpiramide acid Acetyl chloride
3-(METHOXYMETHOXY)BENZALDEHYDE Acetylacetone 6-Aminocaproic acid
chevron_left

1of4

chevron_right
cxd CEFROXADINE 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[(amino-1,4-cyclohexadien-1-ylacetyl)amino]-3-methoxy-8-oxo-, [6R-[6α,7β(R*)]]- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-amino-1,4-cyclohexadien-1-ylacetyl]amino]-3-methoxy-8-oxo-, (6R,7R)- Oraspor (6R,7R)-7-[[(2R)-2-Amino-2-(1-cyclohexa-1,4-dienyl)acetyl]amino]-3-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (6R,7R)-7-[[(R)-Amino(1,4-cyclohexadien-1-yl)acetyl]amino]-3-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid C12979 7-[2-aMino-2-(cyclohexa-2,5-dien-1-yl)acetaMido]-3-Methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (6r-(6-alpha,7-beta(r*)))-ien-1-ylacetyl)amino)-3-methoxy-8-oxo 7-(d-2-amino-2-(1,4-cyclohexadienyl)acetamide)-3-methoxy-3-cephem-4-carboxyl antibioticcgp9000 cefroxadin cgp9000 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-amino-2-(1,4-cyclohexadien-1-yl)acetyl]amino]-3-methoxy-8-oxo-, (6R,7R)- Cefroxadine USP/EP/BP BRN 0587499 Cefroxadine. Oraspor 51762-05-1