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Mivacurium chloride

Mivacurium chloride Structure
CAS No.
106861-44-3
Chemical Name:
Mivacurium chloride
Synonyms
(S)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline;Mivacron;BW-B1090U;rac-Mivacron;rac-BW-B 1090;rac-BW-B 1090U;Lomiwa Reservoir;BMS-512148 (2S)-1;MIVACURIUM CHLORIDE;Mivacarium Chloride
CBNumber:
CB7218031
Molecular Formula:
C58H80ClN2O14+
Molecular Weight:
1064.73
MOL File:
106861-44-3.mol
Modify Date:
2024/11/19 15:53:33
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Mivacurium chloride Properties

alpha 20D -62.7° (c = 1.9 in water)
storage temp. Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility DMSO: Soluble; Water: Soluble
form A solid
color White to off-white
Stability Hygroscopic
InChIKey KFWHZSUNFAPZPW-NVIAPQDINA-M

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501
NFPA 704
0
2 0

Mivacurium chloride Chemical Properties,Uses,Production

Description

Mivacurium chloride,a mixture of three stereoisomers, is an intravenously administered, short-acting skeletal muscle relaxant introduced as an adjunct to general anesthesia. Structurally mivacurium chloride is closely related to doxacurium chloride introduced in 1991 by Wellcome as a muscle relaxant. It is a nondepolarizing neuromuscular blocking agent reportedly with a shorter duration of action and a more rapid rate of spontaneous recovery than other nondepolarizing agents. In extensive clinical trials mivacurium chloride was well tolerated with few side effects.

Chemical Properties

Off-White Solid

Uses

Non-depolarizing neuromuscular blocking agent. Muscle relaxant (skeletal)

Biological Functions

Mivacurium chloride (Mivacron) is a newer agent that is chemically related to atracurium. The primary mechanism of inactivation is hydrolysis by plasma cholinesterase. Although it is useful for patients with renal or hepatic disease, some caution is warranted, since these individuals may have reduced plasma cholinesterase as a result of the disease.Mivacurium has an onset of action (1.8 minutes) and duration of effect (20 minutes) only twice that of succinylcholine, and in this respect, it is the most similar to succinylcholine of all of the nondepolarizing agents.

General Description

Mivacurium chloride, 1,2,3,4-tetrahydro-2-(3-hydroxypropyl)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride, (E)-4-octandioate (Mivacron), is a mixture of three stereoisomers,the trans-trans, cis-trans, and cis-cis diesters, each ofwhich has neuromuscular blocking properties. The cis-cisisomer is about one tenth as potent as the other isomers.Mivacurium chloride is a short-acting nondepolarizing drugused as an adjunct to anesthesia to relax skeletal muscle.The drug is hydrolyzed by plasma esterases, and it is likelythat anticholinesterase agents used as antidotes could prolongrather than reverse the effects of the drug.

Mivacurium chloride Preparation Products And Raw materials

Raw materials

3-Chloro-1-propanol PAPAVERINE HYDROCHLORIDE 2-Butanone CHLOROETHANE Sodium carbonate
L(+)-Tartaric acid DIBENZOATE Sodium iodide MELIBIOSE
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Preparation Products

Mivacurium chloride Suppliers

Global( 126)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Vivimed Labs Ltd +914066086608 Telangana, India 61 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6739 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
Xiamen AmoyChem Co., Ltd +86-86-5926051114 +8618959220845 China 6383 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49374 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29810 58 Inquiry
SIMAGCHEM CORP +86-13806087780 China 17365 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32161 58 Inquiry
Hubei Ipure Biology Co., Ltd +8613367258412 China 10319 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 22787 58 Inquiry
Supplier Advantage
Vivimed Labs Ltd 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
CLEARSYNTH LABS LTD. 58
Xiamen AmoyChem Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58
SIMAGCHEM CORP 58
TargetMol Chemicals Inc. 58
Hubei Ipure Biology Co., Ltd 58
Dideu Industries Group Limited 58

Mivacurium chloride Spectrum

Mivacurium chloride(106861-44-3)1HNMR

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MIVACURIUM CHLORIDE rac Mivacurium Chloride rac-BW-B 1090 rac-Mivacron rel-(1R,1'R)-2,2'-[[(4E)-1,8-Dioxo-4-octene-1,8-diyl]bis(oxy-3,1-propanediyl)]bis[1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]- isoquinolinium Chloride [R-[R*,R*-(E)]]2,2'-(1,8-Dioxo-4-octene-1,8-diyl)bis(oxy-3,1-propanediyl)bis[1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxyphenyl)isoquinolinium] dichloride rac-BW-B 1090U -1，2，3，4-Te．trahydro-2-(3-hydroxypropyl)-6，7-dimethoxy-2-methyl-1-(3，4，5-trimethoxy-benzyl)isoquinolinium chloride，(E)-4-octenedioate(2：1) BW-B1090U Mivacron (1R,1'R)-2,2'-[[(4E)-1,8-Dioxo-4-octene-1,8-diyl]bis(oxy-3,1-propanediyl)]bis[1,2,3,4-tetrahydro-6,7-diMethoxy-2-Methyl-1-[(3,4,5-triMethoxyphenyl)Methyl]-isoquinoliniuM Chloride Mivacurium Chloride (mixture of isomers) Mivacurium Chloride (Mixture of Diastereomers) (R)-3-(6,7-dimethoxy-1-(3,4,5-trimethoxybenzyl)-3,4-dihydroisoquinolin-2(1H)-yl)propan-1-ol (R)-3-(2-chloro-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydro-2l5-isoquinolin-2-yl)propyl acetate (R,E)-9-(3-(2-chloro-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydro-2l5-isoquinolin-2-yl)propoxy)-9-oxonon-5-enoic acid Micuronium Chloride isomers Z-Micuronium Chloride Mivacurium Chloride Impurity 6 Mivacurium Chloride Impurity 7 Micuronium Chloride impurity Mivacurium dichloride Mivacurium chloride USP/EP/BP Mivacarium Chloride Mivacurium Chloride ( isomers) BMS-512148 (2S)-1 Dapagliflozin ((2S)-1 (S)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline Micuronium chloride Lomiwa Reservoir (1R,1'R)-2,2'-((((E)-Oct-4-enedioyl)bis(oxy))bis(propane-3,1-diyl))bis(6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-2-ium) chloride Mivacurium chloride, nicotinic acetylcholine antagonist 106861-44-3 10686-44-3 C58H80Cl2N2O14 Intermediates & Fine Chemicals Neurochemicals Pharmaceuticals API